Reactome | VHL [nucleoplasm]

VHL [nucleoplasm]

Stable Identifier

R-HSA-1234127

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:Q15370 ELOB

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of ubiquitinylation proteins (Homo sapiens)
        
        PIAS4 SUMOylates VHL with SUMO1 (Homo sapiens)
        
        VHL [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P40337 VHL

Gene Names

VHL

Chain

chain:1-213

Reference Genes

BioGPS Gene:7428 VHL

COSMIC (genes):VHL VHL

CTD Gene:7428 VHL

dbSNP Gene:7428 VHL

ENSEMBL:ENSG00000134086 VHL

HGNC:12687 VHL

KEGG:hsa:7428 VHL

Monarch:7428 VHL

NCBI Gene:7428 VHL

OMIM:608537 VHL

UCSC:P40337 VHL

Reference Transcript

Participates

as an input of

PIAS4 SUMOylates VHL with SUMO1 (Homo sapiens)

as a component of

VBC Complex [nucleoplasm] (Homo sapiens)

Other forms of this molecule

VHL [cytosol]

monoSUMO1-K159,171,196-VHL [nucleoplasm]

Inferred To

Vhl [nucleoplasm] (Drosophila melanogaster)

Vhl [nucleoplasm] (Mus musculus)

Vhl [nucleoplasm] (Rattus norvegicus)

vhl [nucleoplasm] (Danio rerio)

VHL [nucleoplasm] (Bos taurus)

VHL [nucleoplasm] (Canis familiaris)

VHL [nucleoplasm] (Gallus gallus)

Ghost homologue of VHL [nucleoplasm] (Sus scrofa)

Ghost homologue of VHL [nucleoplasm] (Xenopus tropicalis)

vhl-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

Guide to Pharmacology - Targets

3204

OpenTargets

ENSG00000134086

ENSEMBL

ENST00000256474, ENSP00000256474, ENST00000345392, ENSP00000344757, ENSG00000134086

HPA

ENSG00000134086-VHL

GeneCards

VHL

ZINC - Substances

VHL_HUMAN

ZINC target

P40337

PRO

P40337

Pharos - Targets

P40337

Orphanet

VHL

ZINC - Predictions - Purchasable

VHL_HUMAN

PDB

6ZHC, 9EQJ, 4BKT, 7Z76, 8EWV, 8BDM, 8G1P, 7ZNT, 6GMR, 4W9J, 8BB4, 5NW1, 8FY1, 8BEB, 7KHH, 5NVW, 5NW2, 6GFY, 6FMI, 4BKS, 4WQO, 5T35, 8VLB, 6R7F, 8QW7, 8BDX, 4W9D, 9BOL, 8QJS, 8BDT, 4W9H, 5NVZ, 8FY2, 3ZTC, 8G1Q, 4B95, 8CQE, 4W9F, 5NW0, 7CJB, 8BB5, 6FMK, 6BVB, 8PC2, 4W9K, 6I7Q, 8R5H, 6SIS, 8RWZ, 6GFX, 8BDO, 4W9E, 4AJY, 9EQM, 5N4W, 8QU8, 8EI3, 8BB2, 7JTO, 3ZRC, 1LM8, 7Z6L, 8BDJ, 5NVY, 8FY0, 9BJU, 8QVU, 7S4E, 1VCB, 7Z77, 6GMN, 5NVV, 8RX0, 8P0F, 6HAX, 8BDL, 8CQK, 6HR2, 8C13, 7Q2J, 4W9C, 4W9L, 6GFZ, 7PI4, 6I7R, 4B9K, 7JTP, 4AWJ, 8QJR, 8WDK, 6GMX, 8BDS, 3ZRF, 4W9I, 3ZTD, 8VL9, 3ZUN, 6R6H, 8BB3, 1LQB, 6HAY, 5NVX, 4W9G, 6GMQ, 6FMJ, 5LLI, 8CQL, 8BDN, 8QW6, 8BDI

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131)	0.962	22
UniProt:Q15370 ELOB	2	ELOB [cytosol] (R-HSA-180551) TCEB2 [nucleoplasm] (R-HSA-112423)	0.94	13
UniProt:Q13617 CUL2	3	CUL2 [cytosol] (R-HSA-416982) CUL2 [nucleoplasm] (R-HSA-1234126) G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511)	0.916	19
UniProt:Q15369 ELOC	2	ELOC [cytosol] (R-HSA-180535) TCEB1 [nucleoplasm] (R-HSA-112422)	0.871	10
UniProt:Q99750 MDFI			0.666	4
UniProt:Q99814 EPAS1 (HIF2A)	5	EPAS1 [cytosol] (R-HSA-1234119) EPAS1 [nucleoplasm] (R-HSA-452560) HN-EPAS1 [cytosol] (R-HSA-1234112) 2xHP-EPAS1 [cytosol] (R-HSA-1234149) 2xHP-EPAS1 [nucleoplasm] (R-HSA-1234151)	0.659	3
UniProt:P62877 RBX1	2	RBX1 [cytosol] (R-HSA-180582) RBX1 [nucleoplasm] (R-HSA-1234142)	0.623	4
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.611	9
UniProt:P21980 TGM2			0.602	10
UniProt:P0C6X7-PRO_0000037322 REP			0.602	7
UniProt:Q99873 PRMT1	2	PRMT1 [cytosol] (R-HSA-9632173) PRMT1 [nucleoplasm] (R-HSA-3215140)	0.508	2
UniProt:Q13231 CHIT1	3	CHIT1 [tertiary granule lumen] (R-HSA-6800898) CHIT1 [extracellular region] (R-HSA-6786396) CHIT1 [specific granule lumen] (R-HSA-6799529)	0.499	2
UniProt:P02751 FN1	10	FN1(32-2477) [extracellular region] (R-HSA-54851) FN1(32-2477) [platelet alpha granule lumen] (R-HSA-114620) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-271) [extracellular region] (R-HSA-3787935)	0.499	2
UniProt:Q61221	7	Hif1a [cytosol] (R-MMU-1234131) Hif1a [nucleoplasm] (R-MMU-1234105) Hif1a [cytosol] (R-MMU-1234110) phospho-Hif1a [cytosol] (R-MMU-9634700) phospho-Hif1a [cytosol] (R-MMU-8857584) Hif1a [cytosol] (R-MMU-1234102) Hif1a [nucleoplasm] (R-MMU-1234135)	0.499	3
UniProt:Q05513 PRKCZ	5	PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.463	3
UniProt:P08151 GLI1	9	GLI1 [ciliary tip] (R-HSA-5610360) GLI1 [ciliary base] (R-HSA-5610357) p-GLI1 [nucleoplasm] (R-HSA-5635042) 2p-GLI1 [nucleoplasm] (R-HSA-5635057) p-GLI1 [ciliary tip] (R-HSA-5635040) GLI1 [cytosol] (R-HSA-445457) pS-GLI1 [ciliary base] (R-HSA-5610497) ub-pS-GLI1 [ciliary base] (R-HSA-5610514) ub-GLI1 [cytosol] (R-HSA-5635833)	0.463	2

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