Reactome | 2xHP-EPAS1 [nucleoplasm]

2xHP-EPAS1 [nucleoplasm]

Stable Identifier

R-HSA-1234151

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

hydroxyPro405,531-EPAS1, hydroxyPro405,531-HIF2A, EPAS1 (HIF2A) with hydroxyproline-405 and -531, Endothelial PAS domain-containing protein 1, EPAS1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q99814 EPAS1

Gene Names

EPAS1, BHLHE73, HIF2A, MOP2, PASD2

Chain

chain:1-870

Reference Genes

BioGPS Gene:2034 EPAS1

COSMIC (genes):EPAS1 EPAS1

CTD Gene:2034 EPAS1

dbSNP Gene:2034 EPAS1

ENSEMBL:ENSG00000116016 EPAS1

HGNC:3374 EPAS1

KEGG:hsa:2034 EPAS1

Monarch:2034 EPAS1

NCBI Gene:2034 EPAS1

OMIM:603349 EPAS1

UCSC:Q99814 EPAS1

Reference Transcript

RefSeq:NM_001430.4 EPAS1

Other Identifiers

11715411_a_at

11715412_a_at

16879721

200878_PM_at

200878_at

200879_PM_s_at

200879_s_at

2034

2480384

2480386

2480387

2480388

2480389

2480390

2480391

2480392

2480420

2480421

2480422

2480424

2480425

2480426

2480427

2480432

2480433

2480434

2480439

2480440

2480441

2480443

2480444

2480445

2480446

2480447

2480448

2480449

2480451

2480453

2480454

2480455

2480456

38230_at

8041781

A_23_P210210

A_23_P430120

GE59478

GE85977

GO:0000785

GO:0000977

GO:0000978

GO:0000981

GO:0000987

GO:0001223

GO:0001228

GO:0001525

GO:0001666

GO:0001892

GO:0001974

GO:0002027

GO:0002070

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006979

GO:0007005

GO:0007165

GO:0007601

GO:0010467

GO:0016071

GO:0016607

GO:0030097

GO:0030154

GO:0030218

GO:0030324

GO:0032364

GO:0042415

GO:0042789

GO:0043129

GO:0043565

GO:0045944

GO:0046982

GO:0046983

GO:0048625

GO:0048856

GO:0050877

GO:0060586

GO:0061629

GO:0071456

GO:0120162

GO:2000434

HMNXSV003057173

Hs.8136.0.S2_3p_at

ILMN_1704753

PH_hs_0011816

PH_hs_0021983

TC02000281.hg

U81984_at

g4503576_3p_a_at

Participates

as an output of

Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)

as a member of

hydroxyPro-HIF-alpha [nucleoplasm] (Homo sapiens)

Other forms of this molecule

EPAS1 [cytosol]

EPAS1 [nucleoplasm]

HN-EPAS1 [cytosol]

2xHP-EPAS1 [cytosol]

Inferred To

EPAS1 [nucleoplasm] (Bos taurus)

EPAS1 [nucleoplasm] (Canis familiaris)

EPAS1 [nucleoplasm] (Gallus gallus)

EPAS1 [nucleoplasm] (Sus scrofa)

epas1 [nucleoplasm] (Xenopus tropicalis)

sima [nucleoplasm] (Drosophila melanogaster)

epas1b [nucleoplasm] (Danio rerio)

hif-1 [nucleoplasm] (Caenorhabditis elegans)

Epas1 [nucleoplasm] (Mus musculus)

Epas1 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

monohydroxylated proline at 405

Coordinate

405

PsiMod Name

monohydroxylated proline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.

Name

monohydroxylated proline at 531

Coordinate

531

PsiMod Name

monohydroxylated proline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.

Cross References

RefSeq

NP_001421.2

Guide to Pharmacology - Targets

3148

OpenTargets

ENSG00000116016

ENSEMBL

ENSP00000263734, ENSG00000116016, ENST00000263734

ZINC - Substances

EPAS1_HUMAN

ZINC target

Q99814

PRO

Q99814

GlyGen

Q99814

PDB

4XT2, 8RUZ, 3H7W, 3F1P, 7Q5V, 3H82, 5KIZ, 3F1N, 6X2H, 3F1O, 8Q5S, 8Q64, 6X28, 6D0B, 6X21, 6D0C, 6BVB, 6I7R, 6D09, 6I7Q, 8Q6E, 4PKY, 8CK4, 1P97, 4GHI, 8Q6D, 8CK8, 6CZW, 4GS9, 6X3D, 5TBM, 5UFP, 8RUT, 6X37, 8CK3, 8RUV, 7UJV, 2A24, 7Q5X, 8RV1

HPA

ENSG00000116016-EPAS1

GeneCards

EPAS1

Pharos - Targets

Q99814

Orphanet

EPAS1

ZINC - Predictions - Purchasable

EPAS1_HUMAN

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27540 ARNT	1	ARNT [nucleoplasm] (R-HSA-1234098)	0.886	8
UniProt:P40337 VHL	3	VHL [cytosol] (R-HSA-391423) VHL [nucleoplasm] (R-HSA-1234127) monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697)	0.659	3
UniProt:Q9GZT9 EGLN1	1	EGLN1 [cytosol] (R-HSA-1234108)	0.635	3
UniProt:P60228 EIF3E	1	EIF3E [cytosol] (R-HSA-72552)	0.602	10
UniProt:P09467 FBP1	1	FBP1 [cytosol] (R-HSA-70476)	0.602	4
UniProt:Q9BWF3-1 RBM4			0.576	6
UniProt:Q9Y2K6 USP20	1	USP20 [cytosol] (R-HSA-5696946)	0.556	3
UniProt:O00327-8 BMAL1			0.556	3
UniProt:Q8WYA1-3 BMAL2			0.556	3
UniProt:P40818 USP8	2	p-T945-USP8 [cytosol] (R-HSA-1358714) USP8 [cytosol] (R-HSA-917720)	0.544	2
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.519	2
UniProt:Q96RK4 BBS4	1	BBS4 [cytosol] (R-HSA-5617635)	0.508	2
UniProt:O60573 EIF4E2	1	EIF4E2 [cytosol] (R-HSA-1678822)	0.499	2