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HIF1AN [cytosol]
Stable Identifier
R-HSA-1234154
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
FIH1, HIF1AN (FIH1), Hypoxia-inducible factor 1-alpha inhibitor, HIF1N_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Homo sapiens)
FIH1:AscH-:Fe2+ dimer [cytosol] (Homo sapiens)
FIH1:AscH-:Fe2+ [cytosol] (Homo sapiens)
HIF1AN [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NWT6 HIF1AN
Gene Names
HIF1AN, FIH1
Chain
initiator methionine:, chain:2-349
Reference Genes
BioGPS Gene:55662 HIF1AN
COSMIC (genes):HIF1AN HIF1AN
CTD Gene:55662 HIF1AN
dbSNP Gene:55662 HIF1AN
ENSEMBL:ENSG00000166135 HIF1AN
HGNC:17113 HIF1AN
KEGG:hsa:55662 HIF1AN
Monarch:55662 HIF1AN
NCBI Gene:55662 HIF1AN
OMIM:606615 HIF1AN
UCSC:Q9NWT6 HIF1AN
Reference Transcript
RefSeq:NM_017902.2 HIF1AN
Other Identifiers
11721869_at
11721870_s_at
11721871_s_at
16708278
218525_3p_s_at
218525_PM_s_at
218525_s_at
226648_PM_at
226648_at
3260667
3260671
3260672
3260673
3260677
3260678
3260679
3260680
3260681
3260682
3260683
3260684
3260685
3260686
3260687
3260689
3260691
3260693
3260695
3260697
55662
59999_PM_at
59999_at
61379_at
65142_at
67441_at
73993_at
7929831
A_14_P117496
A_14_P118368
A_19_P00807243
A_23_P46964
A_32_P84640
GE55573
GE899817
GO:0003714
GO:0003824
GO:0005112
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0008198
GO:0008270
GO:0016491
GO:0019826
GO:0031406
GO:0036139
GO:0036140
GO:0042803
GO:0043226
GO:0045663
GO:0045746
GO:0045892
GO:0046872
GO:0048471
GO:0051059
GO:0051213
GO:0060090
GO:0062101
GO:0071532
GO:0140096
GO:0140110
GO:0140299
GO:2001214
HMNXSV003015725
Hs.119451.0.A1_3p_at
ILMN_1681812
PH_hs_0001380
TC10000724.hg
g8923568_3p_a_at
g8923568_3p_s_at
Participates
as a component of
FIH1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Inferred To
HIF1AN [cytosol]
(Bos taurus)
HIF1AN [cytosol]
(Canis familiaris)
HIF1AN [cytosol]
(Danio rerio)
HIF1AN [cytosol]
(Gallus gallus)
HIF1AN [cytosol]
(Mus musculus)
HIF1AN [cytosol]
(Sus scrofa)
hif1an [cytosol]
(Xenopus tropicalis)
Hif1an [cytosol]
(Rattus norvegicus)
Cross References
OpenTargets
ENSG00000166135
ENSEMBL
ENST00000299163
,
ENSP00000299163
HPA
ENSG00000166135-HIF1AN
ZINC - Substances
HIF1N_HUMAN
ZINC target
Q9NWT6
PRO
Q9NWT6
Pharos - Targets
Q9NWT6
HMDB Protein
HMDBP01023
PDB
2YC0
,
1MZF
,
3KCX
,
2XUM
,
2CGN
,
8IHZ
,
2ILM
,
4Z1V
,
3D8C
,
4B7K
,
3P3P
,
7A1S
,
7A1K
,
8K71
,
6HKP
,
7A1N
,
5OP6
,
1IZ3
,
2W0X
,
7A1O
,
2YDE
,
1H2N
,
1H2M
,
5OP8
,
5OPC
,
5JWK
,
4BIO
,
3P3N
,
4B7E
,
3OD4
,
3KCY
,
2Y0I
,
2CGO
,
6HA6
,
6RUJ
,
1MZE
,
1YCI
,
2WA3
,
4Z2W
,
8K72
,
4JAA
,
7A1L
,
6HL5
,
7A1M
,
6HC8
,
6H9J
,
6HL6
,
8K73
,
5JWP
,
1H2K
,
7A1P
,
7A1Q
,
8II0
,
1H2L
,
7A1J
,
4AI8
,
4NR1
,
5JWL
,
2WA4
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16665 HIF1A
7
HIF1A [nucleoplasm]
(R-HSA-1234135)
HIF1A [cytosol]
(R-HSA-1234102)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
HN-HIF1A [cytosol]
(R-HSA-1234110)
0.922
12
UniProt:Q05823 RNASEL
2
RNASEL [mitochondrial matrix]
(R-HSA-5223312)
RNASEL [cytosol]
(R-HSA-1015684)
0.837
8
UniProt:P25963 NFKBIA
9
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
0.793
7
UniProt:P19838 NFKB1
8
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
0.744
7
UniProt:Q9UM47 NOTCH3
20
Ub-NICD3 [cytosol]
(R-HSA-9021546)
Ub-NEXT3 [plasma membrane]
(R-HSA-9021545)
p-Y-NICD3 [cytosol]
(R-HSA-9018581)
Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
(R-HSA-1911429)
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
(R-HSA-1911419)
NOTCH3(1572-2321) [Golgi membrane]
(R-HSA-156995)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane]
(R-HSA-1983672)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region]
(R-HSA-1983675)
NOTCH3(1572-2321) [plasma membrane]
(R-HSA-157231)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane]
(R-HSA-1472871)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
(R-HSA-1467307)
10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
(R-HSA-1467382)
Pre-NOTCH3 [endoplasmic reticulum membrane]
(R-HSA-157102)
NICD3 [nucleoplasm]
(R-HSA-157928)
NICD3 [cytosol]
(R-HSA-157647)
NEXT3 [plasma membrane]
(R-HSA-157203)
NOTCH3(1629-1661) [plasma membrane]
(R-HSA-157657)
NOTCH3(40-1628) [extracellular region]
(R-HSA-157639)
FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane]
(R-HSA-1911522)
FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane]
(R-HSA-1911517)
0.643
5
UniProt:O60547 GMDS
1
GMDS [cytosol]
(R-HSA-6787620)
0.643
4
UniProt:P40222 TXLNA
1
TXLNA [cytosol]
(R-HSA-449124)
0.643
3
UniProt:Q00653 NFKB2
6
NFKB2(1-454) [nucleoplasm]
(R-HSA-177674)
NFKB2(1-454) [cytosol]
(R-HSA-168144)
p-7S-p100 [cytosol]
(R-HSA-5607629)
K48-polyUb-p-7S-p100 [cytosol]
(R-HSA-5607636)
NFKB2(1-900) [cytosol]
(R-HSA-2677931)
monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol]
(R-HSA-4755500)
0.643
3
UniProt:O75832 PSMD10
1
PSMD10 [cytosol]
(R-HSA-68788)
0.59
2
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.59
2
UniProt:Q5VT52 RPRD2
1
RPRD2 [nucleoplasm]
(R-HSA-6814906)
0.527
2
UniProt:O60733 PLA2G6
2
PLA2G6 [cytosol]
(R-HSA-201596)
PLA2G6 [mitochondrial inner membrane]
(R-HSA-1524076)
0.527
2
UniProt:P47974 ZFP36L2
1
ZFP36L2 [cytosol]
(R-HSA-9819194)
0.527
2
UniProt:Q9BW85 YJU2
1
YJU2 [nucleoplasm]
(R-HSA-9770430)
0.527
3
UniProt:Q9UHD2 TBK1
5
p-S172-TBK1 [cytosol]
(R-HSA-168379)
TBK1 [cytosol]
(R-HSA-166267)
K63polyUb-K30,K401-TBK1 [cytosol]
(R-HSA-9730430)
p-TBK1 [cytosol]
(R-HSA-9008705)
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
0.527
2
UniProt:Q9BZF9 UACA
1
UACA [cytosol]
(R-HSA-6804636)
0.508
2
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