Formation of HIF:CBP:p300 complex at promoters

Stable Identifier
R-HSA-1234167
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

HIF (heterodimer of HIF-alpha and HIF-beta) recruits p300 and CBP to the promoters of target genes (Kallio et al. 1998, Ebert and Bunn 1998, Ema et al. 1999, Gu et al. 2001, Dames et al. 2002, Freedman et al. 2002).

Literature References
PubMed ID Title Journal Year
11959990 Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

Freedman, SJ, Sun, ZY, Poy, F, Kung, AL, Livingston, DM, Wagner, G, Eck, MJ

Proc Natl Acad Sci U S A 2002
10202154 Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300

Ema, M, Hirota, K, Mimura, J, Abe, H, Yodoi, J, Sogawa, K, Poellinger, L, Fujii-Kuriyama, Y

EMBO J 1999
11959977 Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

Dames, SA, Martinez-Yamout, M, De Guzman, RN, Dyson, HJ, Wright, PE

Proc Natl Acad Sci U S A 2002
11063749 Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine

Gu, J, Milligan, J, Huang, LE

J Biol Chem 2001
9822602 Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

Kallio, PJ, Okamoto, K, O'Brien, S, Carrero, P, Makino, Y, Tanaka, H, Poellinger, L

EMBO J 1998
17804822 The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

Hu, CJ, Sataur, A, Wang, L, Chen, H, Simon, MC

Mol Biol Cell 2007
9632793 Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein

Ebert, BL, Bunn, HF

Mol Cell Biol 1998
Participants
Participant Of
This event is regulated
Negatively by
Orthologous Events
Authored
Reviewed
Created