Reactome | ERBB4 binds NRGs or EGF-like ligands

ERBB4 binds NRGs or EGF-like ligands

Stable Identifier

R-HSA-1236398

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

Synonyms

ERBB4 binds neuregulins or EGF-like ligands, NRGs/EGF-like ligands + ERBB4 => NRGs/EGF-like ligands:ERBB4

ReviewStatus

5/5

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All three ERBB4 isoforms are activated by binding of neuregulins (NRG1, NRG2, NRG3 and NRG4) or EGF like growth factors (betacellulin, epiregulin, HB EGF) to their extracellular domain (Tzahar et al. 1994, Riese et al. 1995, Carraway et al. 1997, Elenius et al. 1997, Zhang et al. 1997, Riese et al. 1998, Hayes et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
9168115	Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases Unger, MJ, Carraway KL, 3rd, Gassmann, M, Lai, C, Yu, N, Ledesma, J, Weber, JL	Nature	1997
9135143	Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation Sun, J, Paul, S, Allison, G, Klagsbrun, M, Elenius, K	EMBO J	1997
7565730	The cellular response to neuregulins is governed by complex interactions of the erbB receptor family Andrews, GC, Riese DJ, 2nd, Stern, DF, Plowman, GD, van Raaij, TM	Mol Cell Biol	1995
7929212	ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms Chang, D, Levkowitz, G, Liu, N, Karunagaran, D, Yi, L, Yayon, A, Tzahar, E, Peles, E, Lavi, S, Wen, D	J Biol Chem	1994
9556621	Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2 Riese DJ, 2nd, Komurasaki, T, Stern, DF, Plowman, GD	J Biol Chem	1998
17545517	Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer Baines, AJ, Blackburn, E, Gullick, WJ, Hayes, NV, Frost, TM, Smart, LV, Russell, GA, Morgan, BJ, Boyle, MM	Clin Cancer Res	2007
9275162	Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4 Sun, Y, Frantz, G, Sliwkowski, MX, Crowley, C, Hillan, K, Godowski, PJ, Mark, M, Akita, RW, Brush, J, Zhang, D	Proc Natl Acad Sci U S A	1997