ERBB4 binds NRGs or EGF-like ligands

Stable Identifier
R-HSA-1236398
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
ERBB4 binds neuregulins or EGF-like ligands, NRGs/EGF-like ligands + ERBB4 => NRGs/EGF-like ligands:ERBB4
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All three ERBB4 isoforms are activated by binding of neuregulins (NRG1, NRG2, NRG3 and NRG4) or EGF like growth factors (betacellulin, epiregulin, HB EGF) to their extracellular domain (Tzahar et al. 1994, Riese et al. 1995, Carraway et al. 1997, Elenius et al. 1997, Zhang et al. 1997, Riese et al. 1998, Hayes et al. 2007).

Literature References
PubMed ID Title Journal Year
9135143 Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation

Elenius, K, Paul, S, Allison, G, Sun, J, Klagsbrun, M

EMBO J 1997
9168115 Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases

Carraway KL, 3rd, Weber, JL, Unger, MJ, Ledesma, J, Yu, N, Gassmann, M, Lai, C

Nature 1997
7565730 The cellular response to neuregulins is governed by complex interactions of the erbB receptor family

Riese DJ, 2nd, van Raaij, TM, Plowman, GD, Andrews, GC, Stern, DF

Mol Cell Biol 1995
7929212 ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms

Tzahar, E, Levkowitz, G, Karunagaran, D, Yi, L, Peles, E, Lavi, S, Chang, D, Liu, N, Yayon, A, Wen, D

J Biol Chem 1994
9556621 Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2

Riese DJ, 2nd, Komurasaki, T, Plowman, GD, Stern, DF

J Biol Chem 1998
17545517 Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer

Hayes, NV, Blackburn, E, Smart, LV, Boyle, MM, Russell, GA, Frost, TM, Morgan, BJ, Baines, AJ, Gullick, WJ

Clin Cancer Res 2007
9275162 Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4

Zhang, D, Sliwkowski, MX, Mark, M, Frantz, G, Akita, RW, Sun, Y, Hillan, K, Crowley, C, Brush, J, Godowski, PJ

Proc Natl Acad Sci U S A 1997
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