Peptide loading on MHC class I in phagosome

Stable Identifier
R-HSA-1236971
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Peptides translocated back into the phagosomal lumen are loaded onto MHC class I molecules. Guermonprez et al. (2003) detected the components of the peptide loading complex (TAP, tapasin, calreticulin and ERp57) together with MHC class I in purified early phagosomes. They observed peptide loading in the presence of ATP in purified phagosomes expressing HLA-A2, incubated with iodinated S-9-L peptide. From these experiments they concluded that TAP-imported peptides can be loaded on MHC class I molecules in the lumen of phagosomes. Houde et al. (2003) also observed OVA peptide SIINFEKL:MHC-I complex in the phagosome lumen.

Participants
Participant Of
Inferred From
Authored
Reviewed
Created