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Erythrocytes take up oxygen and release carbon dioxide
Stable Identifier
R-HSA-1247673
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
,
extracellular region
,
plasma membrane
ReviewStatus
5/5
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Transport of small molecules (Homo sapiens)
O2/CO2 exchange in erythrocytes (Homo sapiens)
Erythrocytes take up oxygen and release carbon dioxide (Homo sapiens)
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Erythrocytes circulating through the capillaries of the lung must exchange carbon dioxide (CO2) for oxygen (O2) during their short (0.5-1 sec.) transit time in pulmonary tissue (Reviewed in Jensen 2004, Esbaugh and Tufts 2006, Boron 2010). CO2 bound as carbamate to the N-terminus of hemoglobin and protons (H+) bound to histidine residues in hemoglobin are released as hemoglobin (HbA) binds O2. Bicarbonate (HCO3-) present in plasma is taken up by erythrocytes via the band3 anion exchanger (AE1, SLC4A1) and combined with H+ by carbonic anhydrases I and II (CA1/CA2) to yield water and CO2 (Reviewed by Esbaugh and Tufts 2006). CO2 is passively transported out of the erythrocyte by AQP1 and RhAG. HCO3- in plasma is also directly dehydrated by extracellular carbonic anhydrase IV (CA4) present on endothelial cells lining the capillaries in the lung.
Literature References
PubMed ID
Title
Journal
Year
15491402
Red blood cell pH, the Bohr effect, and other oxygenation-linked phenomena in blood O2 and CO2 transport
Jensen, FB
Acta Physiol Scand
2004
19879980
Evaluating the role of carbonic anhydrases in the transport of HCO3--related species
Boron, WF
Biochim Biophys Acta
2010
16679072
The structure and function of carbonic anhydrase isozymes in the respiratory system of vertebrates
Tufts, BL
,
Esbaugh, AJ
Respir Physiol Neurobiol
2006
Participants
Events
Hemoglobin A binds O2, releasing H+ and CO2
(Homo sapiens)
SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-
(Homo sapiens)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2
(Homo sapiens)
AQP1 tetramer transports CO2 from cytosol to extracellular region
(Homo sapiens)
RHAG transports CO2 from cytosol to extracellular region
(Homo sapiens)
CA4:Zn2+ dehydrates HCO3- to CO2
(Homo sapiens)
Participates
as an event of
O2/CO2 exchange in erythrocytes (Homo sapiens)
Event Information
Go Biological Process
bicarbonate transport (0015701)
Orthologous Events
Erythrocytes take up oxygen and release carbon dioxide (Bos taurus)
Erythrocytes take up oxygen and release carbon dioxide (Caenorhabditis elegans)
Erythrocytes take up oxygen and release carbon dioxide (Canis familiaris)
Erythrocytes take up oxygen and release carbon dioxide (Danio rerio)
Erythrocytes take up oxygen and release carbon dioxide (Dictyostelium discoideum)
Erythrocytes take up oxygen and release carbon dioxide (Drosophila melanogaster)
Erythrocytes take up oxygen and release carbon dioxide (Gallus gallus)
Erythrocytes take up oxygen and release carbon dioxide (Mus musculus)
Erythrocytes take up oxygen and release carbon dioxide (Plasmodium falciparum)
Erythrocytes take up oxygen and release carbon dioxide (Rattus norvegicus)
Erythrocytes take up oxygen and release carbon dioxide (Sus scrofa)
Erythrocytes take up oxygen and release carbon dioxide (Xenopus tropicalis)
Authored
May, B (2011-04-04)
Reviewed
Jassal, B (2012-04-27)
Created
May, B (2011-04-05)
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