GGCT transforms gGluCys to OPRO

Stable Identifier
R-HSA-1247922
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Formation of 5-oxoproline from gamma-glutamylcysteine
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Gamma-glutamylcyclotransferase (GGCT) homodimer (Bae et al. 2008) catalyses the formation of 5-oxoproline from gamma-glutamylcysteine (gGluCys), therby playing a role in glutathione homeostasis (Oakley et al. 2008).

Literature References
PubMed ID Title Journal Year
18515354 The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle

Oakley, AJ, Yamada, T, Liu, D, Coggan, M, Clark, AG, Board, PG

J Biol Chem 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
gamma-glutamylcyclotransferase activity of GGCT dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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