GGCT transforms gGluCys to OPRO

Stable Identifier
R-HSA-1247922
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Formation of 5-oxoproline from gamma-glutamylcysteine
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GGCT transforms gGluCys to OPRO
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Gamma-glutamylcyclotransferase (GGCT) homodimer (Bae et al. 2008) catalyses the formation of 5-oxoproline from gamma-glutamylcysteine (gGluCys), therby playing a role in glutathione homeostasis (Oakley et al. 2008).
Literature References
PubMed ID Title Journal Year
18515354 The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle

Oakley, AJ, Yamada, T, Clark, AG, Coggan, M, Board, PG, Liu, D

J Biol Chem 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

gamma-glutamylcyclotransferase activity of GGCT dimer [cytosol]

Physical Entity
GGCT dimer [cytosol] (Homo sapiens)
Activity
gamma-glutamylcyclotransferase activity (GO:0003839)
Orthologous Events
GGCT transforms gGluCys to OPRO (Bos taurus)
GGCT transforms gGluCys to OPRO (Caenorhabditis elegans)
GGCT transforms gGluCys to OPRO (Canis familiaris)
GGCT transforms gGluCys to OPRO (Danio rerio)
GGCT transforms gGluCys to OPRO (Drosophila melanogaster)
GGCT transforms gGluCys to OPRO (Gallus gallus)
GGCT transforms gGluCys to OPRO (Mus musculus)
GGCT transforms gGluCys to OPRO (Rattus norvegicus)
GGCT transforms gGluCys to OPRO (Sus scrofa)
GGCT transforms gGluCys to OPRO (Xenopus tropicalis)
Authored
Jassal, B  (2011-04-08)
Reviewed
D'Eustachio, P  (2011-05-23)
Created
Jassal, B  (2011-04-08)
Cite Us!