OPLAH hydrolyses OPRO to L-Glu

Stable Identifier
R-HSA-1247935
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cleavage of 5-oxoproline to form glutamate
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OPLAH hydrolyses OPRO to L-Glu
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5-oxoprolinase catalyzes the cleavage of 5-oxoproline to form L-glutamate, coupled to the hydrolysis of ATP to ADP and inorganic phosphate (Chen et al, 1998).

Literature References
PubMed ID Title Journal Year
9516961 Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: a potential new target for biochemical modulation of glutathione

Chen, X, Schecter, RL, Griffith, OW, Hayward, MA, Alpert, LC, Batist, G

Clin Cancer Res 1998
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
5-oxoprolinase (ATP-hydrolyzing) activity of OPLAH [cytosol]
Physical Entity
OPLAH [cytosol]
Activity
5-oxoprolinase (ATP-hydrolyzing) activity (0017168)
Orthologous Events
OPLAH hydrolyses OPRO to L-Glu (Caenorhabditis elegans)
OPLAH hydrolyses OPRO to L-Glu (Canis familiaris)
OPLAH hydrolyses OPRO to L-Glu (Danio rerio)
OPLAH hydrolyses OPRO to L-Glu (Dictyostelium discoideum)
OPLAH hydrolyses OPRO to L-Glu (Drosophila melanogaster)
OPLAH hydrolyses OPRO to L-Glu (Mus musculus)
OPLAH hydrolyses OPRO to L-Glu (Rattus norvegicus)
OPLAH hydrolyses OPRO to L-Glu (Saccharomyces cerevisiae)
OPLAH hydrolyses OPRO to L-Glu (Schizosaccharomyces pombe)
OPLAH hydrolyses OPRO to L-Glu (Sus scrofa)
OPLAH hydrolyses OPRO to L-Glu (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2011-04-08)
Reviewed
D'Eustachio, P  (2011-05-23)
Created
Jassal, B  (2011-04-08)
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