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TXNIP [cytosol]
Stable Identifier
R-HSA-1250246
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Thioredoxin-interacting protein, TXNIP_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O15534 PER1
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
TXNIP binds NLRP3 (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
TXNIP binds NLRP3 (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
TXNIP binds reduced thioredoxin (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
TXNIP is released from oxidized thioredoxin (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
TXNIP binds NLRP3 (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
TXNIP binds reduced thioredoxin (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
TXNIP is released from oxidized thioredoxin (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H3M7 TXNIP
Gene Names
TXNIP, VDUP1
Chain
chain:1-391
Reference Genes
BioGPS Gene:10628 TXNIP
COSMIC (genes):TXNIP TXNIP
CTD Gene:10628 TXNIP
dbSNP Gene:10628 TXNIP
ENSEMBL:ENSG00000265972 TXNIP
ENSEMBL_homo_sapiens_GENE:ENSG00000265972.6 TXNIP
HGNC:16952 TXNIP
KEGG Gene (Homo sapiens):10628 TXNIP
Monarch:10628 TXNIP
NCBI Gene:10628 TXNIP
OMIM:606599 TXNIP
UCSC:Q9H3M7 TXNIP
Reference Transcript
RefSeq:NM_006472.5 TXNIP
RefSeq:NM_001313972.1 TXNIP
Other Identifiers
10628
11717190_s_at
11748543_a_at
11748544_s_at
11752765_s_at
11756431_s_at
16669796
201008_PM_s_at
201008_s_at
201009_PM_s_at
201009_s_at
201010_PM_s_at
201010_s_at
2356116
2356117
2356118
2356120
2356121
2356123
2356125
2356127
2356128
2356130
2356132
2356134
2356135
2356136
2356137
2356138
31508_at
64281_s_at
7904726
A_23_P97700
GE58805
GO:0000122
GO:0004857
GO:0005515
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006606
GO:0006886
GO:0006913
GO:0006954
GO:0006979
GO:0007049
GO:0009410
GO:0009612
GO:0009749
GO:0012501
GO:0015031
GO:0023052
GO:0030154
GO:0030216
GO:0031625
GO:0032355
GO:0032570
GO:0042127
GO:0042542
GO:0043065
GO:0048008
GO:0048856
GO:0051592
GO:0051782
GO:0071228
GO:0098772
GO:0140052
HMNXSV003003998
Hs.179526.0.S1_3p_a_at
Hs.179526.0.S2_3p_a_at
ILMN_1697448
PH_hs_0010634
S73591_at
TC01001090.hg
g5454161_3p_a_at
Participates
as a component of
Oxidized thioredoxin:TXNIP [cytosol] (Homo sapiens)
Thioredoxin:TXNIP [cytosol] (Homo sapiens)
TXNIP:NLRP3 [cytosol] (Homo sapiens)
as an input of
TXNIP binds NLRP3 (Homo sapiens)
TXNIP binds reduced thioredoxin (Homo sapiens)
as an output of
TXNIP is released from oxidized thioredoxin (Homo sapiens)
Other forms of this molecule
TXNIP [nucleoplasm]
Inferred To
Vdup1 [cytosol]
(Drosophila melanogaster)
arrd-23 [cytosol]
(Caenorhabditis elegans)
Dmel\CG14696 [cytosol]
(Drosophila melanogaster)
Dmel\CG18745 [cytosol]
(Drosophila melanogaster)
LDB19 [cytosol]
(Saccharomyces cerevisiae)
CSR2 [cytosol]
(Saccharomyces cerevisiae)
ttm-2 [cytosol]
(Caenorhabditis elegans)
mug170 [cytosol]
(Schizosaccharomyces pombe)
ALY2 [cytosol]
(Saccharomyces cerevisiae)
Dmel\CG18748 [cytosol]
(Drosophila melanogaster)
Dmel\CG18746 [cytosol]
(Drosophila melanogaster)
ECM21 [cytosol]
(Saccharomyces cerevisiae)
ART5 [cytosol]
(Saccharomyces cerevisiae)
Dmel\CG10086 [cytosol]
(Drosophila melanogaster)
TXNIP [cytosol]
(Bos taurus)
TXNIP [cytosol]
(Canis familiaris)
TXNIP [cytosol]
(Gallus gallus)
TXNIP [cytosol]
(Schizosaccharomyces pombe)
TXNIP [cytosol]
(Sus scrofa)
txnipa [cytosol]
(Danio rerio)
Dmel\CG2993 [cytosol]
(Drosophila melanogaster)
Dmel\CG3014 [cytosol]
(Drosophila melanogaster)
Homologues of TXNIP [cytosol]
(Caenorhabditis elegans)
Homologues of TXNIP [cytosol]
(Drosophila melanogaster)
Homologues of TXNIP [cytosol]
(Saccharomyces cerevisiae)
Homologues of TXNIP [cytosol]
(Schizosaccharomyces pombe)
Dmel\CG18744 [cytosol]
(Drosophila melanogaster)
Dmel\CG1105 [cytosol]
(Drosophila melanogaster)
RIM8 [cytosol]
(Saccharomyces cerevisiae)
Txnip [cytosol]
(Mus musculus)
Txnip [cytosol]
(Rattus norvegicus)
ALY1 [cytosol]
(Saccharomyces cerevisiae)
Dmel\CG2641 [cytosol]
(Drosophila melanogaster)
ROD1 [cytosol]
(Saccharomyces cerevisiae)
ROG3 [cytosol]
(Saccharomyces cerevisiae)
Dmel\CG18747 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001300901.1
,
NP_006463.3
OpenTargets
ENSG00000265972
GeneCards
Q9H3M7
HPA
ENSG00000265972-TXNIP
Ensembl
ENSP00000462521
,
ENSG00000265972
,
ENST00000582401
,
ENSP00000396322
,
ENST00000425134
PRO
Q9H3M7
Pharos - Targets
Q9H3M7
PDB
4ROJ
,
4GEI
,
4ROF
,
5DF6
,
4LL1
,
5DWS
,
5DZD
,
5CQ2
,
4GEJ
,
4LL4
,
4GFX
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10599 TXN
4
2xHC-TXN [nucleoplasm]
(R-HSA-9617733)
TXN [nucleoplasm]
(R-HSA-9617732)
2xHC-TXN [cytosol]
(R-HSA-73668)
TXN [cytosol]
(R-HSA-66000)
0.743
8
UniProt:O95905 ECD
0.688
6
UniProt:P52735 VAV2
2
VAV2 [cytosol]
(R-HSA-195012)
p-Y172-VAV2 [cytosol]
(R-HSA-442307)
0.558
2
UniProt:Q9H0M0 WWP1
1
WWP1 [cytosol]
(R-HSA-976037)
0.527
2
UniProt:Q658Y4 FAM91A1
1
FAM91A1 [cytosol]
(R-HSA-9714670)
0.527
2
UniProt:Q99757 TXN2
2
TXN2 [mitochondrial matrix]
(R-HSA-3323048)
2xHC-TXN2 [mitochondrial matrix]
(R-HSA-3323059)
0.527
2
UniProt:Q8WVZ9 KBTBD7
1
KBTBD7 [cytosol]
(R-HSA-5658415)
0.527
2
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.527
2
UniProt:Q9NS91 RAD18
1
RAD18 [nucleoplasm]
(R-HSA-5643731)
0.527
2
UniProt:Q8WXI9 GATAD2B
1
GATAD2B [nucleoplasm]
(R-HSA-3702079)
0.527
2
UniProt:Q9NXF7 DCAF16
1
DCAF16 [nucleoplasm]
(R-HSA-8955193)
0.527
2
UniProt:O15534 PER1
4
p-S-PER1 [cytosol]
(R-HSA-400310)
p-S-PER1 [nucleoplasm]
(R-HSA-3325590)
PER1 [cytosol]
(R-HSA-400373)
Ub-p-S-PER1 [cytosol]
(R-HSA-517831)
0.527
2
UniProt:Q86V97 KBTBD6
1
KBTBD6 [cytosol]
(R-HSA-8863221)
0.527
2
UniProt:Q92769 HDAC2
2
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
HDAC2 [nucleoplasm]
(R-HSA-205135)
0.499
3
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