SHC1 events in ERBB4 signaling

Stable Identifier
R-HSA-1250347
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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SHC1 events in ERBB4 signaling
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All splicing isoforms of ERBB4 possess two tyrosine residues in the C-tail that serve as docking sites for SHC1 (Kaushansky et al. 2008, Pinkas-Kramarski et al. 1996, Cohen et al. 1996). Once bound to ERBB4, SHC1 becomes phosphorylated on tyrosine residues by the tyrosine kinase activity of ERBB4, which enables it to recruit the complex of GRB2 and SOS1, resulting in the guanyl-nucleotide exchange on RAS and activation of RAF and MAP kinase cascade (Kainulainen et al. 2000).
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Events
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Orthologous Events
SHC1 events in ERBB4 signaling (Bos taurus)
SHC1 events in ERBB4 signaling (Canis familiaris)
SHC1 events in ERBB4 signaling (Danio rerio)
SHC1 events in ERBB4 signaling (Drosophila melanogaster)
SHC1 events in ERBB4 signaling (Gallus gallus)
SHC1 events in ERBB4 signaling (Mus musculus)
SHC1 events in ERBB4 signaling (Rattus norvegicus)
SHC1 events in ERBB4 signaling (Sus scrofa)
SHC1 events in ERBB4 signaling (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Orlic-Milacic, M  (2011-11-04)
Stern, DF  (2019-02-21)
Reviewed
Zeng, F  (2011-11-11)
Harris, RC  (2011-11-11)
Earp HS, 3rd  (2012-02-20)
Misior, AM  (2012-02-20)
Created
Orlic-Milacic, M  (2011-04-18)
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