Phosphorylation of SHC1 by ERBB4 homodimers

Stable Identifier
R-HSA-1250348
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of SHC1 by ERBB4 homodimers
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After binding ERBB4 homodimers, SHC1 gets phosphorylated on tyrosine residues Y349 and Y350 (Kainulainen et al. 2000).
Literature References
PubMed ID Title Journal Year
10722704 A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis

Kainulainen, V, Sundvall, M, Määttä, JA, Santiestevan, E, Klagsbrun, M, Elenius, K

J Biol Chem 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of SHC1:p-ERBB4 [plasma membrane]

Physical Entity
SHC1:p-ERBB4 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation of SHC1 by ERBB4 homodimers (Bos taurus)
Phosphorylation of SHC1 by ERBB4 homodimers (Canis familiaris)
Phosphorylation of SHC1 by ERBB4 homodimers (Drosophila melanogaster)
Phosphorylation of SHC1 by ERBB4 homodimers (Gallus gallus)
Phosphorylation of SHC1 by ERBB4 homodimers (Mus musculus)
Phosphorylation of SHC1 by ERBB4 homodimers (Rattus norvegicus)
Phosphorylation of SHC1 by ERBB4 homodimers (Sus scrofa)
Phosphorylation of SHC1 by ERBB4 homodimers (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2011-11-04)
Stern, DF  (2019-02-21)
Reviewed
Harris, RC  (2011-11-11)
Zeng, F  (2011-11-11)
Earp HS, 3rd  (2012-02-20)
Misior, AM  (2012-02-20)
Created
Orlic-Milacic, M  (2011-04-18)
Cite Us!