Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers

Stable Identifier
R-HSA-1250370
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
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Activated PI3K bound to phosphorylated ERBB4 CYT-1 homodimers converts PIP2 into PIP3, which leads to activation of AKT signaling (Kainulainen et al. 2000).
Literature References
PubMed ID Title Journal Year
10722704 A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis

Santiestevan, E, Sundvall, M, Kainulainen, V, Määttä, JA, Elenius, K, Klagsbrun, M

J Biol Chem 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K:p-ERBB4cyt1 [plasma membrane]

Physical Entity
PI3K:p-ERBB4cyt1 [plasma membrane] (Homo sapiens)
Activity
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
Orthologous Events
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Caenorhabditis elegans)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Danio rerio)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Drosophila melanogaster)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Gallus gallus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Mus musculus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Rattus norvegicus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Sus scrofa)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Xenopus tropicalis)
Cross References
Rhea
Authored
Orlic-Milacic, M  (2011-11-04)
Stern, DF  (2019-02-21)
Reviewed
Zeng, F  (2011-11-11)
Harris, RC  (2011-11-11)
Earp HS, 3rd  (2012-02-20)
Misior, AM  (2012-02-20)
Created
Orlic-Milacic, M  (2011-04-18)
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