PLCG1 phosphorylation by p-EGFR:p-ERBB2

Stable Identifier
R-HSA-1251922
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phospholipase C gamma 1 (PLCG1) is phosphorylated by phosphorylated EGFR:ERBB2 heterodimer.

Literature References
PubMed ID Title Journal Year
1672440 The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency

Fazioli, F, Kim, UH, Rhee, SG, Molloy, CJ, Segatto, O, Di Fiore, PP

Mol Cell Biol 1991
8940074 The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells

Cohen, BD, Kiener, PA, Green, JM, Foy, L, Fell, HP, Zhang, K

J Biol Chem 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed