Cleavage of P-ERBB4jmA isoforms by ADAM17

Stable Identifier
R-HSA-1251992
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylated ligand-bound homodimers of ERBB4 JM-A isoforms are cleaved by ADAM17 metalloproteinase to yield ligand-bound ERBB4 extracellular domain and membrane bound ERBB4 fragment of 80 kDa (ERBB4m80) (Rio et al. 2000, Cheng et al. 2003).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of ADAM17 [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created