Cleavage of ERBB4m80 by gamma-scretase complex

Stable Identifier
R-HSA-1251997
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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After ERBB4 is cleaved by ADAM17, gamma-secretase complex performs additional cleavage in the transmembrane region of the m80 ERBB4 fragment, releasing the soluble ERBB4 intracellular domain of 80 kDa, known as s80 or E4ICD (Ni et al. 2001).

Literature References
PubMed ID Title Journal Year
11679632 gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

Ni, CY, Murphy, MP, Golde, TE, Carpenter, G

Science 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of gamma-secretase complex [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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