ERBB4 ubiquitination by WWP1/ITCH

Stable Identifier
R-HSA-1253282
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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Upon binding to ERBB4 or its cleavage products m80 and s80, NEDD4 family ligases WWP1 and ITCH ubiquitinate intact and cleaved ERBB4 and target it for degradation (Omerovic et al. 2007, Feng et al. 2009).

Literature References
PubMed ID Title Journal Year
17463226 The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation

Omerovic, J, Santangelo, L, Puggioni, EM, Marrocco, J, Dall'Armi, C, Palumbo, C, Belleudi, F, Di Marcotullio, L, Frati, L, Torrisi, MR, Cesareni, G, Gulino, A, Alimandi, M

FASEB J 2007
19047365 The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation

Feng, SM, Muraoka-Cook, RS, Hunter, D, Sandahl, MA, Caskey, LS, Miyazawa, K, Atfi, A, Earp HS, 3rd

Mol Cell Biol 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of ERBB4/m80/s80:WWP1/ITCH [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created