Reactome | TAB2 [nucleoplasm]

TAB2 [nucleoplasm]

Stable Identifier

R-HSA-1253323

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mitogen-activated protein kinase kinase kinase 7 interacting protein 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NYJ8 TAB2

Gene Names

TAB2, KIAA0733, MAP3K7IP2

Chain

chain:1-693

Reference Genes

BioGPS Gene:23118 TAB2

COSMIC (genes):TAB2 TAB2

CTD Gene:23118 TAB2

dbSNP Gene:23118 TAB2

ENSEMBL:ENSG00000055208 TAB2

HGNC:17075 TAB2

KEGG Gene (Homo sapiens):23118 TAB2

Monarch:23118 TAB2

NCBI Gene:23118 TAB2

OMIM:605101 TAB2

UCSC:Q9NYJ8 TAB2

Reference Transcript

Other Identifiers

0001580632

0005290484

11743012_at

11750741_a_at

11754101_x_at

11757315_s_at

17013567

210284_s_at

212184_s_at

23118

2930603

2930606

2930616

2930623

2930624

2930627

2930628

2930629

2930633

2930635

2930636

2930637

2930642

2930643

2930644

2930645

2930646

2930647

2930648

2930649

2930650

2930651

2930652

2930706

2DAE

2WWZ

2WX0

2WX1

38980_at

65436

70137

71215

8122672

A0A1B0GV57

A_14_P121269

A_14_P135290

A_23_P19702

A_33_P3404331

AAF67176

AAH35910

AB018276

ABC40736

AF241230

AK315038

AL031133

AL117407

AL138727

AL139103

BAA34453

BAG37521

BC035910

CAB55907

CAG33668

CCDS5214

CH471051

CR457387

DQ314877

EAW47805

EAW47806

EAW47807

ENSG00000055208

ENSP00000356426

ENSP00000432709

ENSP00000445752

ENSP00000490618

ENST00000367456

ENST00000367456.5

ENST00000470466

ENST00000470466.5

ENST00000538427

ENST00000538427.5

ENST00000637181

ENST00000637181.1

EntrezGene:23118

EntrezGene:TAB2

g7677465_3p_a_at

GE56455

GO:0000187

GO:0002223

GO:0002376

GO:0002755

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0006464

GO:0006914

GO:0006950

GO:0007165

GO:0007249

GO:0007254

GO:0007507

GO:0008150

GO:0009056

GO:0009058

GO:0010008

GO:0010507

GO:0016020

GO:0031410

GO:0032496

GO:0034641

GO:0038095

GO:0043123

GO:0043167

GO:0043226

GO:0045860

GO:0046872

GO:0048856

GO:0050852

GO:0051092

GO:0070423

GO:0070498

GO:0070530

HGNC:17075

HPA065436

HPA070137

HPA071215

Hs.109727.1.S1_3p_a_at

ILMN_1672331

ILMN_1808322

IPR001876

IPR003892

IPR036443

IPR041911

MIM:605101

MIM:614980

NM_001292034

NM_015093

NP_001278963

NP_055908

PF02845

PH_hs_0006053

PH_hs_0040402

SM00546

SM00547

TAB2

TAB2-201

TAB2-203

TAB2-205

TAB2-209

U3KQ62

U3KQR0

UPI0000072F70

UPI0000073C75

XM_011535633

XM_017010591

XM_017010592

XP_011533935

XP_016866080

XP_016866081

Participant Of

hasComponent

TAB2:NCOR1 [nucleoplasm]

Other forms of this molecule

TAB2 [cytosol]

TAB2 [plasma membrane]

TAB2 [endosome membrane]

TAB2 [cytosol]

Inferred To

TAB2 [nucleoplasm] (Bos taurus)

TAB2 [nucleoplasm] (Canis familiaris)

TAB2 [nucleoplasm] (Danio rerio)

TAB2 [nucleoplasm] (Gallus gallus)

TAB2 [nucleoplasm] (Mus musculus)

TAB2 [nucleoplasm] (Rattus norvegicus)

TAB2 [nucleoplasm] (Sus scrofa)

TAB2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

XP_011533935.1, NP_001278963.1, XP_016866080.1, XP_016866081.1, NP_055908.1, NP_001278964.1

OpenTargets

ENSG00000055208

GeneCards

Q9NYJ8

PRO

Q9NYJ8

Orphanet

24961

PDB

2WWZ, 2DAE, 2WX1, 2WX0

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43318 MAP3K7	10	K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) p-MAP3K7 [cytosol] (R-HSA-168163) MAP3K7 [plasma membrane] (R-HSA-9012677) p-T187-MAP3K7 [cytosol] (R-HSA-206014) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.839	6
UniProt:Q9Y4K3 TRAF6	8	K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.678	3
UniProt:Q62073 Map3k7	10	PolyUb-MAP3K7 [cytosol] (R-MMU-6782968) Phospho TAK1 [cytosol] (R-MMU-205840) K63polyUb-34,158-TAK1 [cytosol] (R-MMU-5607643) phospho-K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-MMU-5607649) phospho-p-MAP3K7 [cytosol] (R-MMU-168163) phospho-p-T187-MAP3K7 [cytosol] (R-MMU-206014) MAP3K7 [endosome membrane] (R-MMU-450315) phospho-p-T184,T187-MAP3K7 [endosome membrane] (R-MMU-450332) MAP3K7 [cytosol] (R-MMU-168156) phospho-p-T184,T187-MAP3K7 [cytosol] (R-MMU-202527)	0.59	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.564	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG [nucleoplasm] (R-HSA-4755413) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) IKBKG [cytosol] (R-HSA-168108) K63polyUb-NEMO [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397)	0.488	2
UniProt:P52747 ZNF143	1	ZNF143 [nucleoplasm] (R-HSA-83837)	0.488	2