Reactome | WWOX [cytosol]

WWOX [cytosol]

Stable Identifier

R-HSA-1253335

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

WW domain-containing oxidoreductase, FOR, WOX1

Locations in the PathwayBrowser for interactor UniProt:Q96G27 WBP1

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
      - Negative regulation of activity of TFAP2 (AP-2) family transcription factors (Homo sapiens)
        
        WWOX binds TFAP2C (Homo sapiens)
        
        WWOX [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NZC7 WWOX

Gene Names

WWOX, FOR, SDR41C1, WOX1

Chain

chain:1-414

Reference Genes

COSMIC (genes):WWOX WWOX

dbSNP Gene:51741 WWOX

ENSEMBL:ENSG00000186153 WWOX

Participates

as an input of

as a component of

Inferred To

WWOX [cytosol] (Bos taurus)

WWOX [cytosol] (Canis familiaris)

WWOX [cytosol] (Danio rerio)

WWOX [cytosol] (Drosophila melanogaster)

WWOX [cytosol] (Gallus gallus)

WWOX [cytosol] (Mus musculus)

WWOX [cytosol] (Sus scrofa)

dhs-7 [cytosol] (Caenorhabditis elegans)

Ghost homologue of WWOX [cytosol] (Xenopus tropicalis)

Wwox [cytosol] (Rattus norvegicus)

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96AW1 VOPP1			0.693	7
UniProt:Q96G27 WBP1			0.688	4
UniProt:P81408 EREP3			0.641	5
UniProt:O15350 TP73	3	PolyUb-TP73 [cytosol] (R-HSA-8957256) TP73 [cytosol] (R-HSA-8957239) TP73 [nucleoplasm] (R-HSA-6798094)	0.641	4
UniProt:Q99732 LITAF			0.61	5
UniProt:O15350-2 TP73			0.61	5
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.569	3
UniProt:Q8N114 SHISA5	2	SHISA5 [endoplasmic reticulum lumen] (R-HSA-8956782) p-SHISA5 [endoplasmic reticulum lumen] (R-HSA-8956987)	0.524	2
UniProt:Q61527	14	phospho-ERBB4jmAcyt2s80 [nucleoplasm] (R-MMU-1252010) phospho-ERBB4jmAcyt1s80 [nucleoplasm] (R-MMU-1252017) phospho-ERBB4jmAcyt1s80 [mitochondrial matrix] (R-MMU-1254405) phospho-ERBB4jmAcyt2s80 [mitochondrial matrix] (R-MMU-1254387) phospho-ERBB4jmAcyt2m80 [plasma membrane] (R-MMU-1251984) phospho-ERBB4jmAcyt1m80 [plasma membrane] (R-MMU-1252004) phospho-ERBB4jmAcyt2s80 [cytosol] (R-MMU-1251987) phospho-ERBB4jmAcyt1s80 [cytosol] (R-MMU-1251964) phospho-p-Y1172,Y1226-ERBB4 JM-A CYT-2 isoform [plasma membrane] (R-MMU-1250307) ERBB4 JM-A CYT-1 isoform [plasma membrane] (R-MMU-1227940) ERBB4 JM-B CYT-1 isoform [plasma membrane] (R-MMU-1233232) ERBB4 JM-A CYT-2 isoform [plasma membrane] (R-MMU-1233237) phospho-p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform [plasma membrane] (R-MMU-1250319) phospho-p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform [plasma membrane] (R-MMU-1250313)	0.463	3
UniProt:Q67FY2	1	Bcl9l [nucleoplasm] (R-MMU-3305843)	0.463	3
UniProt:O15350-1 TP73			0.463	3

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