Reactome | WWOX binds ERBB4s80

WWOX binds ERBB4s80

Stable Identifier

R-HSA-1253343

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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WWOX binds to ERBB4s80 through WW-domain binding motifs in the C-tail of ERBB4. Formation of ERBB4s80:WWOX complex competes with the formation of ERBB4:YAP1 complex and prevents translocation of ERBB4s80 to the nucleus. Feng et al. established that WWOX binds with the same affinity to s80CYT1 and s80CYT2, and identified PY3 as the most important WW-domain binding motif for WWOX binding (Aqeilan et al. 2005, Feng et al. 2009, Schuchardt et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
19047365	The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation Earp HS, 3rd, Muraoka-Cook, RS, Hunter, D, Caskey, LS, Sandahl, MA, Atfi, A, Miyazawa, K, Feng, SM	Mol Cell Biol	2009
16061658	WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function Trapasso, F, Kaou, M, Pekarsky, Y, Donati, V, Aqeilan, RI, Croce, CM, Sudol, M, Palamarchuk, A	Cancer Res	2005
24308844	Molecular origin of the binding of WWOX tumor suppressor to ErbB4 receptor tyrosine kinase Farooq, A, McDonald, CB, Sudol, M, Schuchardt, BJ, Bhat, V, Mikles, DC	Biochemistry	2013