Translocation of ERBB4s80:YAP1 complex to the nucleus

Stable Identifier
R-HSA-1254248
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Upon formation of ERBB4s80:YAP1 complex in the cytosol, the complex translocates to the nucleus, where it may act as a regulator of transcription (Komuro et al. 2003, Omerovic et al. 2004, Aqeilan et al. 2005).

Literature References
PubMed ID Title Journal Year
16061658 WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function

Aqeilan, RI, Donati, V, Palamarchuk, A, Trapasso, F, Kaou, M, Pekarsky, Y, Sudol, M, Croce, CM

Cancer Res 2005
12807903 WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus

Komuro, A, Nagai, M, Navin, NE, Sudol, M

J Biol Chem 2003
15023535 Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level

Omerovic, J, Puggioni, EM, Napoletano, S, Visco, V, Fraioli, R, Frati, L, Gulino, A, Alimandi, M

Exp Cell Res 2004
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