Reactome | Translocation of ERBB4s80:YAP1 complex to the nucleus

Translocation of ERBB4s80:YAP1 complex to the nucleus

Stable Identifier

R-HSA-1254248

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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Translocation of ERBB4s80:YAP1 complex to the nucleus

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Upon formation of ERBB4s80:YAP1 complex in the cytosol, the complex translocates to the nucleus, where it may act as a regulator of transcription (Komuro et al. 2003, Omerovic et al. 2004, Aqeilan et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
12807903	WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus Komuro, A, Nagai, M, Navin, NE, Sudol, M	J Biol Chem	2003
16061658	WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function Aqeilan, RI, Donati, V, Palamarchuk, A, Trapasso, F, Kaou, M, Pekarsky, Y, Sudol, M, Croce, CM	Cancer Res	2005
15023535	Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level Omerovic, J, Puggioni, EM, Napoletano, S, Visco, V, Fraioli, R, Frati, L, Gulino, A, Alimandi, M	Exp Cell Res	2004