Reactome | Translocation of cytosolic ERBB4s80 to mitochondrial matrix

Translocation of cytosolic ERBB4s80 to mitochondrial matrix

Stable Identifier

R-HSA-1254376

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, mitochondrial matrix

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Translocation of cytosolic ERBB4s80 to mitochondrial matrix

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Cytosolic ERBB4s80 is able to translocate to mitochondria where its BH3 domain, characteristic of BCL2 family members, may enable it to act as a pro-apoptotic factor (Naresh et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16778220	The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells Naresh, A, Long, W, Vidal, GA, Wimley, WC, Marrero, L, Sartor, CI, Tovey, S, Cooke, TG, Bartlett, JM, Jones, FE	Cancer Res	2006