Translocation of cytosolic ERBB4s80 to mitochondrial matrix

Stable Identifier
R-HSA-1254376
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Cytosolic ERBB4s80 is able to translocate to mitochondria where its BH3 domain, characteristic of BCL2 family members, may enable it to act as a pro-apoptotic factor (Naresh et al. 2006).

Literature References
PubMed ID Title Journal Year
16778220 The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells

Naresh, A, Long, W, Vidal, GA, Wimley, WC, Marrero, L, Sartor, CI, Tovey, S, Cooke, TG, Bartlett, JM, Jones, FE

Cancer Res 2006
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