Reactome | HSPD1(1-573) [mitochondrial intermembrane space]

HSPD1(1-573) [mitochondrial intermembrane space]

Stable Identifier

R-HSA-1267963

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial intermembrane space

Synonyms

HSP60 precursor, 60 kDa heat shock protein, mitochondrial, HSPD1, CH60_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P10809 HSPD1

Gene Names

HSPD1, HSP60

Chain

transit peptide:1-26, chain:27-573

Reference Genes

BioGPS Gene:3329 HSPD1

COSMIC (genes):HSPD1 HSPD1

CTD Gene:3329 HSPD1

dbSNP Gene:3329 HSPD1

ENSEMBL:ENSG00000144381 HSPD1

HGNC:5261 HSPD1

KEGG:hsa:3329 HSPD1

Monarch:3329 HSPD1

NCBI Gene:3329 HSPD1

OMIM:118190 HSPD1

UCSC:P10809 HSPD1

Reference Transcript

Other Identifiers

11737053_s_at

11745851_x_at

11746986_x_at

11753017_s_at

11753018_x_at

11757531_x_at

11763017_at

11763018_x_at

16906962

200806_PM_s_at

200806_s_at

200807_PM_s_at

200807_s_at

241716_PM_at

241716_at

243372_PM_at

243372_at

2593737

2593738

2593739

2593740

2593741

2593742

2593743

2593744

2593745

2593746

2593747

2593748

2593749

2593750

2593752

2593753

2593754

2593755

2593756

2593757

2593758

2593759

2593760

2593761

2593762

2593763

2593764

2593765

2593766

2593767

2593769

2593770

2593771

2593772

2593773

2593774

2593775

2593788

2593789

2669035

2804031

2804032

2804035

2804036

2916228

2931975

3329

3403532

3417063

3442921

37720_at

3927935

8058052

81838_at

A_32_P25273

A_32_P76091

GE55300

GE570401

GO:0001530

GO:0002039

GO:0002376

GO:0002755

GO:0002842

GO:0003677

GO:0003688

GO:0003697

GO:0003723

GO:0003725

GO:0003824

GO:0005515

GO:0005524

GO:0005615

GO:0005737

GO:0005739

GO:0005743

GO:0005759

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0005905

GO:0006310

GO:0006457

GO:0006458

GO:0006919

GO:0006986

GO:0007005

GO:0008035

GO:0008289

GO:0008637

GO:0009409

GO:0009986

GO:0016020

GO:0016787

GO:0016853

GO:0016887

GO:0019899

GO:0030135

GO:0030141

GO:0031410

GO:0031625

GO:0032727

GO:0032729

GO:0032733

GO:0032735

GO:0032755

GO:0032991

GO:0034185

GO:0034186

GO:0034514

GO:0042026

GO:0042100

GO:0042110

GO:0042113

GO:0043032

GO:0043065

GO:0043066

GO:0043226

GO:0043231

GO:0044183

GO:0045041

GO:0046696

GO:0048291

GO:0050821

GO:0050870

GO:0051082

GO:0051087

GO:0051131

GO:0051604

GO:0051702

GO:0055085

GO:0065003

GO:0070062

GO:0097225

GO:0097524

GO:0098761

GO:0140494

GO:0140657

GO:0140662

HMNXSV003040438

Hs.160227.0.A1_3p_at

Hs.205173.0.A1_3p_at

Hs.259742.0.A1_3p_at

Hs.79037.0.A1_3p_a_at

ILMN_1766713

ILMN_1774410

ILMN_1784367

ILMN_2381397

M22382_at

PH_hs_0028995

PH_hs_0040685

TC02002648.hg

g4504520_3p_a_at

Participates

as a candidate of

Other forms of this molecule

HSPD1(1-573) [cytosol]

HSPD1(1-26) [mitochondrial matrix]

HSPD1(1-573) [mitochondrial inner membrane]

HSPD1 [mitochondrial inner membrane]

HSPD1 [mitochondrial matrix]

Cross References

OpenTargets

ENSG00000144381

ENSEMBL

ENST00000439605, ENSP00000412717, ENSP00000402478, ENST00000678761, ENST00000388968, ENSP00000396460, ENST00000452200, ENST00000418022, ENSP00000340019, ENSP00000503139, ENSP00000414446, ENST00000426480, ENST00000677913, ENST00000428204, ENSP00000412227, ENST00000345042, ENSP00000503894, ENSP00000373620

HPA

ENSG00000144381-HSPD1

PRO

P10809

Pharos - Targets

P10809

GlyGen

P10809

Orphanet

HSPD1

PDB

7AZP, 8G7J, 7L7S, 8G7K, 4PJ1, 6HT7, 6MRC, 6MRD, 8G7O, 8G7M, 8G7L, 8G7N

Interactors (106)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.788	24
UniProt:Q9BRK4 LZTS2			0.781	7
UniProt:Q9NTG7 SIRT3	2	SIRT3(?-399) [mitochondrial matrix] (R-HSA-1605416) SIRT3 [nucleoplasm] (R-HSA-9622879)	0.731	5
UniProt:Q6PI48 DARS2	1	DARS2 [mitochondrial matrix] (R-HSA-379679)	0.731	5
UniProt:Cerebral CLONE			0.718	6
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.718	6
UniProt:O15382 BCAT2	1	PXLP-BCAT2 [mitochondrial matrix] (R-HSA-70703)	0.713	5
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.666	5
UniProt:Q8N6K7 SAMD3			0.666	4
UniProt:Q9Y6E7 SIRT4	1	SIRT4 [mitochondrial matrix] (R-HSA-5687775)	0.643	3
UniProt:P51553 IDH3G	3	IDH3G(1-393) [mitochondrial intermembrane space] (R-HSA-1267970) IDH3G(1-393) [cytosol] (R-HSA-1267969) IDH3G [mitochondrial matrix] (R-HSA-70964)	0.641	3
UniProt:P49590 HARS2	1	HARS2 [mitochondrial matrix] (R-HSA-379581)	0.615	5
UniProt:Q4G176 ACSF3	1	ACSF3 [mitochondrial matrix] (R-HSA-5696011)	0.615	5
UniProt:Q96I59 NARS2	1	NARS2 [mitochondrial matrix] (R-HSA-379585)	0.615	4
UniProt:A8MXV4 NUDT19	2	NUDT19 [cytosol] (R-HSA-9033098) NUDT19 [peroxisomal matrix] (R-HSA-6809219)	0.615	5
UniProt:Q15120 PDK3	1	PDK3(?-406) [mitochondrial matrix] (R-HSA-203940)	0.615	3
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.615	5
UniProt:O75323 GBAS	1	NIPSNAP2 [cytosol] (R-HSA-9714668)	0.615	3
UniProt:Q5T440 CAF17			0.615	4
UniProt:Q9BZE1 MRPL37	1	MRPL37 [mitochondrial inner membrane] (R-HSA-5368240)	0.615	4
UniProt:P24539 ATP5PB	1	ATP5PB [mitochondrial inner membrane] (R-HSA-164537)	0.615	3
UniProt:Q9Y2Z4 YARS2	1	YARS2 [mitochondrial matrix] (R-HSA-379634)	0.615	3
UniProt:Q96CB9 NSUN4	1	NSUN4 [mitochondrial matrix] (R-HSA-6793068)	0.615	5
UniProt:Q9NVI7 ATD3A			0.576	4
UniProt:Q9JJY3	1	SMPD3 [plasma membrane] (R-MMU-1606265)	0.563	3
UniProt:Q9Y4C4 MFHA1			0.558	3
UniProt:Q9UBU7 DBF4	1	DBF4 [nucleoplasm] (R-HSA-68387)	0.556	3
UniProt:P12036 NFH			0.556	3
UniProt:O76081-6 RGS20			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q6ZQX7-4 Q6ZQX74			0.556	3
UniProt:Q8WUY3 PRUN2			0.556	3
UniProt:Q6NXG1 ESRP1	3	ESRP1(1-606)-RAF1(227-648) fusion [cytosol] (R-HSA-6802312) ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol] (R-HSA-6802523) ESRP1 [nucleoplasm] (R-HSA-6803472)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:P61158 ACTR3	1	ACTR3 [cytosol] (R-HSA-200811)	0.556	3
UniProt:Q14847-2 LASP1			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q99944 EGFL8			0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
IntAct:EBI-25861394 CCSB			0.556	3
UniProt:Q9UMX3 BOK			0.556	3
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) proHRAS [cytosol] (R-HSA-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:O76081 RGS20	1	RGS20 [plasma membrane] (R-HSA-921136)	0.556	3
UniProt:Q9UBQ0-2 VPS29			0.556	3
UniProt:O77932 DXO			0.556	3
UniProt:Q99504 EYA3	2	p-EYA3 [nucleoplasm] (R-HSA-5683979) EYA3 [nucleoplasm] (R-HSA-5683622)	0.556	3
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189)	0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	6
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:Q9HD33 MRPL47	1	MRPL47 [mitochondrial inner membrane] (R-HSA-5368180)	0.536	2
UniProt:Q8WV16 DCAF4	1	DCAF4 [nucleoplasm] (R-HSA-8955191)	0.527	4
UniProt:Q8N0Z8 PUSL1			0.527	3
UniProt:Q96EF6 FBXO17	1	FBXO17 [cytosol] (R-HSA-976036)	0.527	3
UniProt:O95900 TRUB2			0.527	3
UniProt:Q96BQ3 TRI43			0.527	3
UniProt:Q9BYC2 OXCT2	1	OXCT2 [mitochondrial matrix] (R-HSA-8955625)	0.527	2
UniProt:Q9UFN0 NPS3A			0.527	4
UniProt:P58557 YBEY			0.527	2
UniProt:Q9BXR0 QTRT1	1	QTRT1 [mitochondrial outer membrane] (R-HSA-6782424)	0.527	2
UniProt:Q7Z2T5 TRM1L			0.527	2
UniProt:Q96S79 RSLAB			0.527	3
UniProt:Q9NX20 MRPL16	1	MRPL16 [mitochondrial inner membrane] (R-HSA-5368216)	0.527	2
UniProt:Q6P2I3 FAH2B			0.527	4
UniProt:Q8N5S1 S2541			0.527	2
UniProt:Q92519 TRIB2			0.527	2
UniProt:Q8WUT9 S2543			0.527	2
UniProt:Q96HP4 OXND1			0.527	2
UniProt:Q9H4K7 MTG2			0.527	3
UniProt:Q8N3Z3 GTPB8			0.527	3
UniProt:Q9UI43 MRM2	1	FTSJ2 [mitochondrial matrix] (R-HSA-6793061)	0.527	4
UniProt:Q8IXQ9 ETFBKMT	1	ETFBKMT [mitochondrial matrix] (R-HSA-8876686)	0.527	3
UniProt:Q9BT17 MTG1			0.527	3
UniProt:A6NCF5 KLH33			0.527	3
UniProt:Q0P651 ABD18			0.527	3
UniProt:Q96JK2 DCAF5	1	DCAF5 [nucleoplasm] (R-HSA-8955189)	0.527	4
UniProt:Q5VTA0 PRA17			0.527	2
UniProt:Q9NR28 DIABLO	2	DIABLO [mitochondrial intermembrane space] (R-HSA-64637) DIABLO [cytosol] (R-HSA-114298)	0.527	5
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:Q8WVM0 TFB1M	1	TFB1M [mitochondrial matrix] (R-HSA-1592207)	0.527	3
UniProt:Q96GW9 MARS2	1	MARS2 [mitochondrial matrix] (R-HSA-379555)	0.527	4
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.508	2
UniProt:P16885 PLCG2	8	p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [cytosol] (R-HSA-984806) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.488	2
UniProt:Q96RP9 GFM1	1	GFM1 [mitochondrial matrix] (R-HSA-5389859)	0.483	3
UniProt:Q9BPW8 NIPS1			0.483	2
UniProt:Q96EL2 MRPS24	1	MRPS24 [mitochondrial inner membrane] (R-HSA-5368211)	0.483	3
UniProt:Q9BXW7 HDHD5			0.483	3
UniProt:Q5T9A4 ATAD3B	3	ATAD3B [secretory granule membrane] (R-HSA-6801313) ATAD3B [plasma membrane] (R-HSA-6806518) ATAD3B [ficolin-1-rich granule membrane] (R-HSA-6801277)	0.483	2
UniProt:O75306 NDUFS2	1	NDUFS2 [mitochondrial matrix] (R-HSA-6788520)	0.483	2
UniProt:Q7Z4G4 TRMT11	1	TRMT11 [cytosol] (R-HSA-6786497)	0.483	3
UniProt:P22830 FECH	1	FECH [mitochondrial inner membrane] (R-HSA-189441)	0.483	4
UniProt:Q9NP92 MRPS30	1	MRPS30 [mitochondrial inner membrane] (R-HSA-5368258)	0.483	2
UniProt:Q9BYD3 MRPL4	1	MRPL4 [mitochondrial inner membrane] (R-HSA-5368212)	0.483	3
UniProt:Q16822 PCK2	1	PCK2 [mitochondrial matrix] (R-HSA-372815)	0.483	2
UniProt:O00746 NME4	1	NME4 [mitochondrial inner membrane] (R-HSA-60026)	0.483	3
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.483	5
UniProt:P13073 COX4I1	2	COX4I1 [mitochondrial intermembrane space] (R-HSA-9865413) COX4I1 [mitochondrial inner membrane] (R-HSA-164305)	0.483	2
UniProt:Q16795 NDUFA9	1	NDUFA9 [mitochondrial matrix] (R-HSA-163942)	0.483	3
UniProt:Q9NUJ1 ABHD10	1	ABHD10 [mitochondrial matrix] (R-HSA-5694577)	0.483	2
UniProt:Q9H7S9 ZNF703	1	ZNF703 [nucleoplasm] (R-HSA-2454149)	0.462	4

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