Reactome | HSPA9(1-679) [mitochondrial intermembrane space]

HSPA9(1-679) [mitochondrial intermembrane space]

Stable Identifier

R-HSA-1267968

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial intermembrane space

Synonyms

HSPA9 (mtHsp70) precursor, Stress-70 protein, mitochondrial, GRP75_HUMAN, HSPA9

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P38646 HSPA9

Gene Names

HSPA9, Stress-70 protein, mitochondrial, GRP75, HSPA9B, mt-HSP70

Chain

transit peptide:1-46, chain:47-679

Reference Genes

BioGPS Gene:3313 HSPA9

COSMIC (genes):HSPA9 HSPA9

CTD Gene:3313 HSPA9

dbSNP Gene:3313 HSPA9

ENSEMBL:ENSG00000113013 HSPA9

HGNC:5244 HSPA9

KEGG:hsa:3313 HSPA9

Monarch:3313 HSPA9

NCBI Gene:3313 HSPA9

OMIM:600548 HSPA9

UCSC:P38646 HSPA9

Reference Transcript

RefSeq:NM_004134.6 HSPA9

Other Identifiers

11742920_a_at

11742921_s_at

11750745_a_at

11752595_a_at

11759417_s_at

17000485

17000518

17000520

200690_PM_at

200690_at

200691_PM_s_at

200691_s_at

200692_PM_s_at

200692_s_at

232200_PM_at

232200_at

241840_PM_at

241840_at

2529286

2529292

2529293

2877509

2877510

2877511

2877512

2877513

2877514

2877515

2877516

2877517

2877518

2877519

2877520

2877521

2877522

2877523

2877524

2877525

2877526

2877527

2877528

2877529

2877530

2877531

2877533

2877535

2877537

2877538

2877541

2877543

2877546

2877547

2877548

2877549

2877550

2877551

2877552

3313

41509_at

41510_s_at

75250_s_at

8114455

8114468

86392_at

A_21_P0000296

A_24_P77676

A_24_P934295

GE57605

GE84964

GO:0001401

GO:0003723

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005730

GO:0005737

GO:0005739

GO:0005743

GO:0005744

GO:0005759

GO:0005925

GO:0006457

GO:0006611

GO:0006886

GO:0006913

GO:0007005

GO:0007007

GO:0016226

GO:0016787

GO:0016887

GO:0019899

GO:0030154

GO:0030218

GO:0031072

GO:0031625

GO:0036444

GO:0042026

GO:0042645

GO:0043065

GO:0043066

GO:0043226

GO:0044183

GO:0045646

GO:0045647

GO:0051082

GO:0051085

GO:0055085

GO:0061024

GO:0070062

GO:0140275

GO:0140657

GO:0140662

GO:1902037

GO:1903707

HMNXSV003003490

HMNXSV003015869

Hs.184233.0.A1_3p_at

Hs.254467.0.S1_3p_at

ILMN_1679209

ILMN_1885801

L11066_at

L15189_s_at

PH_hs_0029370

TC05001832.hg

TC05001833.hg

TC05001834.hg

g12653414_3p_a_at

g4758569_3p_a_at

Participates

as a component of

MIB [mitochondrial inner membrane] (Homo sapiens)

as an input of

Formation of MIB complex containing the MICOS complex causes curvature of mitochondrial inner membrane (Homo sapiens)

as a candidate of

Cargo of TOMM40 [mitochondrial intermembrane space] (Homo sapiens)

Other forms of this molecule

HSPA9(1-679) [cytosol]

HSPA9 [mitochondrial inner membrane]

HSPA9 [mitochondrial matrix]

HSPA9 [nucleoplasm]

HSPA9 [cytosol]

Cross References

ENSEMBL

ENSP00000297185, ENST00000297185

OpenTargets

ENSG00000113013

HPA

ENSG00000113013-HSPA9

PRO

P38646

Pharos - Targets

P38646

Orphanet

HSPA9

GlyGen

P38646

PDB

6PMT, 6NHK, 4KBO, 3N8E, 6P2U

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.811	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.745	5
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.742	14
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.706	23
UniProt:Q9HAV7 GRPEL1	1	GRPEL1 [mitochondrial inner membrane] (R-HSA-1252062)	0.669	5
UniProt:P21912 SDHB	2	SDHB [mitochondrial inner membrane] (R-HSA-70985) SDHB [mitochondrial matrix] (R-HSA-9854983)	0.662	10
UniProt:O15350 TP73	3	PolyUb-TP73 [cytosol] (R-HSA-8957256) TP73 [cytosol] (R-HSA-8957239) TP73 [nucleoplasm] (R-HSA-6798094)	0.637	11
UniProt:Q9H6A0 DENND2D	1	DENND2D [cytosol] (R-HSA-8876071)	0.623	3
UniProt:P13693 TCTP			0.567	4
UniProt:P53051 MALX3			0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:A4D2J0 A4D2J0			0.556	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.527	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.527	2
UniProt:Q92733 PRCC	1	PRCC [nucleoplasm] (R-HSA-8867896)	0.527	2
UniProt:Q8ND83 SLAI1			0.527	2
UniProt:Q96NG3 ODAD4			0.527	2
UniProt:O75165 DNAJC13	3	DNAJC13 [azurophil granule membrane] (R-HSA-6799140) DNAJC13 [plasma membrane] (R-HSA-6806255) DNAJC13 [secretory granule membrane] (R-HSA-6800951)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	3
UniProt:Q5SXM8 DNLZ			0.527	2
UniProt:Q99592 ZBT18			0.527	2
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.527	2
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.527	2
UniProt:Q8WX92 NELFB	3	NELFB [mitochondrial outer membrane] (R-HSA-9603553) NELFB [cytosol] (R-HSA-9603526) NELFB [nucleoplasm] (R-HSA-112427)	0.524	2
UniProt:Q99650 OSMR	1	OSMR [plasma membrane] (R-HSA-448654)	0.499	4
UniProt:Q9H1K1 ISCU	1	ISCU [cytosol] (R-HSA-9771680)	0.499	3
UniProt:Q8TDU6 GPBAR1	1	GPBAR1 [plasma membrane] (R-HSA-444640)	0.463	3
UniProt:Q5U5X0 LYRM7	1	LYRM7 [mitochondrial matrix] (R-HSA-9866252)	0.462	2
UniProt:A6NFY7 SDHAF1	1	SDHAF1 [mitochondrial matrix] (R-HSA-9854988)	0.462	2
UniProt:P47985 UQCRFS1	3	UQCRFS1(1-274) [mitochondrial matrix] (R-HSA-9906006) UQCRFS1(1-274) [mitochondrial inner membrane] (R-HSA-9906005) UQCRFS1(79-274) [mitochondrial inner membrane] (R-HSA-164278)	0.462	4
UniProt:Q00005 2ABB			0.462	2
UniProt:Q8N0X7 SPART			0.462	2

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