Reactome | VDAC1 [mitochondrial outer membrane]

VDAC1 [mitochondrial outer membrane]

Stable Identifier

R-HSA-1267988

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Voltage-dependent anion-selective channel protein 1, VDAC1_HUMAN

Icon

Locations in the PathwayBrowser for interactor UniProt:P30041 PRDX6

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External Reference Information

External Reference

UniProt:P21796 VDAC1

Gene Names

VDAC1, VDAC

Chain

initiator methionine:1, chain:2-283

Reference Genes

BioGPS Gene:7416 VDAC1

COSMIC (genes):VDAC1 VDAC1

CTD Gene:7416 VDAC1

dbSNP Gene:7416 VDAC1

ENSEMBL:ENSG00000213585 VDAC1

HGNC:12669 VDAC1

KEGG Gene (Homo sapiens):7416 VDAC1

Monarch:7416 VDAC1

NCBI Gene:7416 VDAC1

OMIM:604492 VDAC1

UCSC:P21796 VDAC1

Reference Transcript

Other Identifiers

0005690121

11715655_s_at

16999985

212038_s_at

217140_s_at

2370085

2683588

2875955

2875956

2875957

2875958

2875959

2875960

2875961

2875962

2875963

2875964

2875965

2875966

2875967

2875968

2875980

31608_g_at

3456919

3982776

3982780

3982781

4008064

4008066

4008075

4008077

4014643

40198_at

4033601

7416

8114145

A_23_P144816

GE57563

GO:0001662

GO:0003674

GO:0005253

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005739

GO:0005741

GO:0005757

GO:0005886

GO:0006090

GO:0006810

GO:0006811

GO:0006820

GO:0006851

GO:0006914

GO:0006915

GO:0006950

GO:0007005

GO:0007267

GO:0007268

GO:0007270

GO:0007612

GO:0008021

GO:0008150

GO:0008219

GO:0008308

GO:0009056

GO:0015288

GO:0015698

GO:0016020

GO:0016021

GO:0016032

GO:0016236

GO:0019899

GO:0019901

GO:0022857

GO:0030154

GO:0030855

GO:0031410

GO:0032991

GO:0042645

GO:0043226

GO:0044281

GO:0044325

GO:0044403

GO:0044877

GO:0045121

GO:0046930

GO:0048856

GO:0050877

GO:0055085

GO:0070062

GO:0098656

GO:1903146

GO:2000378

Hs.149155.2.A1_3p_a_at

ILMN_1774605

ILMN_2175601

L06132_at

PH_hs_0030040

TC05001785.hg

TC05003242.hg

Participant Of

hasMember

VDAC1,2,3 [mitochondrial outer membrane]

hasCandidate

input

Parkin promotes the ubiquitination of mitochondrial substrates

Other forms of this molecule

VDAC1 [mitochondrial intermembrane space]

PolyUb-VDAC1 [mitochondrial outer membrane]

K48polyUb-VDAC1 [mitochondrial outer membrane]

Inferred To

Porin2 [mitochondrial outer membrane] (Drosophila melanogaster)

vdac1 [mitochondrial outer membrane] (Danio rerio)

vdac1 [mitochondrial outer membrane] (Xenopus tropicalis)

VDAC1 [mitochondrial outer membrane] (Canis familiaris)

VDAC1 [mitochondrial outer membrane] (Gallus gallus)

VDAC1 [mitochondrial outer membrane] (Plasmodium falciparum)

VDAC1 [mitochondrial outer membrane] (Schizosaccharomyces pombe)

VDAC1 [mitochondrial outer membrane] (Sus scrofa)

vdac-1 [mitochondrial outer membrane] (Caenorhabditis elegans)

POR1 [mitochondrial outer membrane] (Saccharomyces cerevisiae)

CG31722 [mitochondrial outer membrane] (Drosophila melanogaster)

CG31722-B [mitochondrial outer membrane] (Drosophila melanogaster)

POR2 [mitochondrial outer membrane] (Saccharomyces cerevisiae)

porA [mitochondrial outer membrane] (Dictyostelium discoideum)

porin [mitochondrial outer membrane] (Drosophila melanogaster)

Vdac1 [mitochondrial outer membrane] (Mus musculus)

Vdac1 [mitochondrial outer membrane] (Rattus norvegicus)

Homologues of VDAC1 [mitochondrial outer membrane] (Drosophila melanogaster)

Homologues of VDAC1 [mitochondrial outer membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_003365.1, XP_016865310.1, XP_016865312.1, XP_016865311.1, XP_005272132.1

OpenTargets

ENSG00000213585

HPA

ENSG00000213585-VDAC1

GeneCards

P21796

Ensembl

ENSP00000378487, ENSP00000265333, ENSP00000378484, ENST00000265333, ENST00000395044, ENST00000395047, ENSG00000213585

PRO

P21796

Orphanet

26468

HMDB Protein

HMDBP02507

PDB

6TIR, 5JDP, 2K4T, 5XDO, 2JK4, 6G73, 6TIQ, 5XDN, 6G6U

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21796 VDAC1	4	PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988)	0.655	4
UniProt:P0C0U1 PB1	2	PB1-F2 [cytosol] (R-FLU-169216) PB1-F2 [mitochondrial intermembrane space] (R-FLU-5146789)	0.591	4
UniProt:P15336 ATF2	2	p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243) ATF2 [nucleoplasm] (R-HSA-450336)	0.576	3
UniProt:P12236 SLC25A6	2	SLC25A6 [mitochondrial inner membrane] (R-HSA-49745) SLC25A6 [mitochondrial intermembrane space] (R-HSA-1955374)	0.564	4
UniProt:P81605 DCD	4	DCD(20-110) [extracellular region] (R-HSA-6802997) DCD(20-62) [extracellular region] (R-HSA-6802986) DCD(63-110) [extracellular region] (R-HSA-6802991) DCD(63-109) [extracellular region] (R-HSA-6801811)	0.564	2
UniProt:Q9Y277 VDAC3	2	PolyUb-VDAC3 [mitochondrial outer membrane] (R-HSA-6783045) VDAC3 [mitochondrial outer membrane] (R-HSA-5696901)	0.564	2
UniProt:P06753 TPM3	1	TPM3 [cytosol] (R-HSA-390543)	0.564	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.564	3
UniProt:Q07813	2	Bax [cytosol] (R-MMU-139907) Bax [mitochondrial outer membrane] (R-MMU-139949)	0.544	2
UniProt:Q7L3V2 BOP			0.544	2
UniProt:Q16611 BAK1	2	BAK1 activated [mitochondrial outer membrane] (R-HSA-50690) BAK1 [mitochondrial outer membrane] (R-HSA-139896)	0.544	2
UniProt:Q9H9B4 SFXN1			0.527	4
UniProt:P27824 CANX	2	CANX [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P27105 STOM	4	STOM [plasma membrane] (R-HSA-6806258) STOM [tertiary granule membrane] (R-HSA-6800960) STOM [azurophil granule membrane] (R-HSA-6800997) STOM [specific granule membrane] (R-HSA-6799569)	0.508	2
UniProt:P06493 CDK1	10	CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) CDK1 [cytosol] (R-HSA-170075) p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078)	0.499	3
UniProt:P30041 PRDX6	3	PRDX6 [azurophil granule lumen] (R-HSA-6798744) PRDX6 [extracellular region] (R-HSA-6806198) PRDX6 [cytosol] (R-HSA-3343670)	0.499	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.499	5
UniProt:P45880 VDAC2	2	PolyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-6783185) VDAC2 [mitochondrial outer membrane] (R-HSA-5696880)	0.499	5
UniProt:P38646 HSPA9	6	HSPA9 [cytosol] (R-HSA-5251993) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964)	0.463	2
UniProt:Q14643 ITPR1	2	ITPR1 [endoplasmic reticulum membrane] (R-HSA-3006433) ITPR1 [platelet dense tubular network membrane] (R-HSA-3325593)	0.463	3
UniProt:P04578-PRO_0000038428 ENV			0.462	2

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