SPRY2 binds CBL

Stable Identifier
R-HSA-1295622
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The N terminal TKB domain of CBL binds to the phospho-tyrosine 55 of SPRY2, targeting SPRY2 for degradation by the 26S proteasome. Y55 is also a binding site for PP2A, which dephosphorylates numerous serine and threonine residues on SPRY2, allowing a conformational change that may promote a SPRY2:GRB2 interaction and limit the extent of MAPK activation following FGF stimulation.

Literature References
PubMed ID Title Journal Year
11053437 Evidence for direct interaction between Sprouty and Cbl

Wong, ES, Lim, J, Low, BC, Chen, Q, Guy, GR

J Biol Chem 2001
12593796 hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl

Hall, AB, Jura, N, DaSilva, J, Jang, YJ, Gong, D, Bar-Sagi, D

Curr Biol 2003
12815057 Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function

Fong, CW, Leong, HF, Wong, ES, Lim, J, Yusoff, P, Guy, GR

J Biol Chem 2003
Participants
Participant Of
Orthologous Events
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