SPRY2 binds CBL

Stable Identifier
R-HSA-1295622
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The N terminal TKB domain of CBL binds to the phospho-tyrosine 55 of SPRY2, targeting SPRY2 for degradation by the 26S proteasome. Y55 is also a binding site for PP2A, which dephosphorylates numerous serine and threonine residues on SPRY2, allowing a conformational change that may promote a SPRY2:GRB2 interaction and limit the extent of MAPK activation following FGF stimulation.

Participants
Participant Of
Orthologous Events