SPRY2 binds CBL

Stable Identifier
R-HSA-1295622
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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SPRY2 binds CBL
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The N terminal TKB domain of CBL binds to the phospho-tyrosine 55 of SPRY2, targeting SPRY2 for degradation by the 26S proteasome. Y55 is also a binding site for PP2A, which dephosphorylates numerous serine and threonine residues on SPRY2, allowing a conformational change that may promote a SPRY2:GRB2 interaction and limit the extent of MAPK activation following FGF stimulation.
Literature References
PubMed ID Title Journal Year
12593796 hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl

Hall, AB, Jura, N, Gong, D, DaSilva, J, Bar-Sagi, D, Jang, YJ

Curr Biol 2003
11053437 Evidence for direct interaction between Sprouty and Cbl

Low, BC, Wong, ES, Chen, Q, Lim, J, Guy, GR

J Biol Chem 2001
12815057 Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function

Yusoff, P, Fong, CW, Wong, ES, Lim, J, Leong, HF, Guy, GR

J Biol Chem 2003
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Orthologous Events
SPRY2 binds CBL (Bos taurus)
SPRY2 binds CBL (Canis familiaris)
SPRY2 binds CBL (Danio rerio)
SPRY2 binds CBL (Drosophila melanogaster)
SPRY2 binds CBL (Mus musculus)
SPRY2 binds CBL (Rattus norvegicus)
SPRY2 binds CBL (Sus scrofa)
Authored
Rothfels, K  (2011-08-15)
Reviewed
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2011-05-18)
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