ATP sensitive Potassium channels

Stable Identifier
R-HSA-1296025
Type
Pathway
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser
ATP sensitive K+ channels couple intracellular metabolism with membrane excitability. These channels are inhibited by ATP so are open in low metabolic states and close in high metabolic states, resulting in membrane depolarization triggering responses such as insulin secretion, modulation of vascular smooth muscle and cardioprotection. The channel comprises four Kir6.x subunits and four regulatory sulphonylurea receptors (SUR) (Akrouh et al, 2009).
Literature References
PubMed ID Title Journal Year
19787700 Molecular biology of K(ATP) channels and implications for health and disease

Halcomb, SE, Akrouh, A, Sala-Rabanal, M, Nichols, CG

IUBMB Life 2009
18258787 Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil

Randall, VA, Shorter, K, Picksley, SM, Farjo, NP

FASEB J 2008
Participants
Participates
Event Information
Orthologous Events
Authored
Reviewed
Created
Cite Us!