Activation of Potassium transport channels

Stable Identifier
R-HSA-1296045
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Homotetramers of Kir 1.1 function as inwardly rectifying potassium transport channels. Ki 1.1 are found on the apical side of the cells in the ascending limp of loop of henle and upon activation transport K+ into the extracellular space. Heterotetramers of Kir 4.1 and Ki 5.1 are found on the basolateral side of cells in the distal convoluted tube. Activation of kir 4.1 and 5.1 heterotetramers leads to efflux of K+ into the extracellular space.

Literature References
PubMed ID Title Journal Year
19221509 The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating

Fallen, K, Banerjee, S, Sheehan, J, Addison, D, Lewis, LM, Meiler, J, Denton, JS

Channels (Austin) 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inward rectifier potassium channel activity of Potassium transport channels (Kir 1.1 and Kir 4.1/5.1) [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed