Ca2+ activated K+ channels

Stable Identifier
R-HSA-1296052
Type
Pathway
Species
Homo sapiens
Compartment
Synonyms
Ca activated K+ channels
Locations in the PathwayBrowser
Summation

Ca2+ activated potassium channels are expressed in neuronal and non-neuronal tissue such as smooth muscle, epithelial cell and sensory cells. Ca2+ activated potassium channels are activated when the Ca2+ ion concentration increased, The efflux of K+ via these channels leads to repolarization/hyperpolarization of the membrane potential which limits the Ca2+ influx though voltage activated Ca2+ channels (VGCC) thereby regulating the influx of Ca2+ flow via VGCC.

Literature References
PubMed ID Title Journal Year
20178789 Large conductance, Ca2+-activated K+ channels (BKCa) and arteriolar myogenic signaling

Hill, MA, Yang, Y, Ella, SR, Davis, MJ, Braun, AP

FEBS Lett 2010
19074509 Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation

Sheng, JZ, Ella, S, Davis, MJ, Hill, MA, Braun, AP

FASEB J 2009
20859064 Novel spliced variants of large-conductance Ca(2+)-activated K(+)-channel ?2-subunit in human and rodent pancreas

Ohya, S, Fujimori, T, Kimura, T, Yamamura, H, Imaizumi, Y

J Pharmacol Sci 2010
19149539 The intermediate-conductance Ca2+ -activated K+ channel (KCa3.1) in vascular disease

Tharp, DL, Bowles, DK

Cardiovasc Hematol Agents Med Chem 2009
Participants
Participant Of
Orthologous Events
Authored
Reviewed