G protein gated Potassium channels

Stable Identifier
R-HSA-1296059
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Pathway
Species
Homo sapiens
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Inwardly rectifying G protein activated K+ channels (GIRK) are tetrameric assemblies of Ki3 3 family subunits (Kir 3.1, 3.2 3.3 and 3.4). The activation of G protein coupled receptor by ligand results in the liberation of G alpha and G beta gamma subunits. Gbeta gamma subunits interact and activate GIRK channels.

Literature References
PubMed ID Title Journal Year
20921230 Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate

D'Avanzo, N, Cheng, WW, Doyle, DA, Nichols, CG

J Biol Chem 2010
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