Potassium Channels

Stable Identifier
R-HSA-1296071
Type
Pathway
Species
Homo sapiens
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Summation

Potassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation of action potentials in cardiac muscle and help release of insulin form pancreatic beta cells.
Broadly K+ channels are classified into voltage gated K+ channels, Hyperpolarization activated cyclic nucleotide gated K+ channels (HCN), Tandem pore domain K+ channels, Ca2+ activated K+ channels and inwardly rectifying K+ channels.

Literature References
PubMed ID Title Journal Year
1822292 New insights into the structure and function of potassium channels

MacKinnon, R

Curr Opin Neurobiol 1991
20213494 HCN-related channelopathies

Baruscotti, M, Bottelli, G, Milanesi, R, DiFrancesco, JC, DiFrancesco, D

Pflugers Arch 2010
19584315 Hyperpolarization-activated cation channels: from genes to function

Biel, M, Wahl-Schott, C, Michalakis, S, Zong, X

Physiol Rev 2009
20086079 Inwardly rectifying potassium channels: their structure, function, and physiological roles

Hibino, H, Inanobe, A, Furutani, K, Murakami, S, Findlay, I, Kurachi, Y

Physiol Rev 2010
20813163 Neuronal voltage-gated K+ (Kv) channels function in macromolecular complexes

Norris, AJ, Foeger, NC, Nerbonne, JM

Neurosci Lett 2010
18446619 Surface expression and distribution of voltage-gated potassium channels in neurons (Review)

McKeown, L, Swanton, L, Robinson, P, Jones, OT

Mol Membr Biol 2008
18413784 Potassium channels: newly found players in synaptic plasticity

Kim, J, Hoffman, DA

Neuroscientist 2008
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