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KCNK1 [plasma membrane]
Stable Identifier
R-HSA-1296345
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Potassium channel subfamily K member 1, KCNK1_HUMAN
Locations in the PathwayBrowser
Expand all
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Phase 4 - resting membrane potential (Homo sapiens)
KCNK dimers transport K+ from cytosol to extracellular region (Homo sapiens)
KCNK dimers [plasma membrane] (Homo sapiens)
TWIK1 dimers [plasma membrane] (Homo sapiens)
KCNK1 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Potassium Channels (Homo sapiens)
Tandem pore domain potassium channels (Homo sapiens)
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) (Homo sapiens)
Activation of tandem pore domain in a weak inwardly rectifying K+ channels (Homo sapiens)
TWIK channels [plasma membrane] (Homo sapiens)
TWIK1 dimers [plasma membrane] (Homo sapiens)
KCNK1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00180 KCNK1
Gene Names
KCNK1, HOHO1, KCNO1, TWIK1
Chain
chain:1-336
Reference Genes
BioGPS Gene:3775 KCNK1
COSMIC (genes):KCNK1 KCNK1
CTD Gene:3775 KCNK1
dbSNP Gene:3775 KCNK1
ENSEMBL:ENSG00000135750 KCNK1
HGNC:6272 KCNK1
Monarch:3775 KCNK1
NCBI Gene:3775 KCNK1
OMIM:601745 KCNK1
UCSC:O00180 KCNK1
Reference Transcript
RefSeq:NM_002245.3 KCNK1
Other Identifiers
11728842_a_at
11747096_a_at
204678_PM_s_at
204678_s_at
204679_PM_at
204679_at
2385877
2385884
2385886
2385887
2385888
2385890
2385892
2385897
2385900
2385908
2385913
2385914
2385915
2385918
2385919
2385920
2385921
2385922
2385924
37552_at
3775
7910611
A_14_P115075
A_14_P202239
A_23_P126075
A_33_P3358277
GE59092
GO:0005215
GO:0005242
GO:0005267
GO:0005272
GO:0005515
GO:0005768
GO:0005886
GO:0006813
GO:0008076
GO:0014047
GO:0015271
GO:0016020
GO:0016324
GO:0022834
GO:0022841
GO:0030322
GO:0030425
GO:0031410
GO:0031526
GO:0034705
GO:0035094
GO:0035725
GO:0042802
GO:0042995
GO:0043204
GO:0043226
GO:0043231
GO:0045202
GO:0046982
GO:0055037
GO:0055085
GO:0060075
GO:0071805
GO:0097060
GO:1902476
GO:1902937
GO:1905030
HMNXSV003042593
HMNXSV003048239
ILMN_1718863
ILMN_2071641
PH_hs_0024272
U33632_at
U90065_s_at
g1916294_3p_a_at
g4504846_3p_at
Participates
as a component of
TWIK1 dimers [plasma membrane] (Homo sapiens)
Inferred To
TOK1 [plasma membrane]
(Saccharomyces cerevisiae)
twk-46 [plasma membrane]
(Caenorhabditis elegans)
KCNK1 [plasma membrane]
(Bos taurus)
KCNK1 [plasma membrane]
(Canis familiaris)
KCNK1 [plasma membrane]
(Sus scrofa)
Kcnk1 [plasma membrane]
(Mus musculus)
Kcnk1 [plasma membrane]
(Rattus norvegicus)
kcnk1a [plasma membrane]
(Danio rerio)
KCNK7 [plasma membrane]
(Gallus gallus)
kcnk1 [plasma membrane]
(Xenopus tropicalis)
Cross References
Guide to Pharmacology - Targets
513
ENSEMBL
ENSP00000355580
,
ENST00000366621
OpenTargets
ENSG00000135750
HPA
ENSG00000135750-KCNK1
PRO
O00180
Pharos - Targets
O00180
GlyGen
O00180
HMDB Protein
HMDBP10851
PDB
3UKM
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
5
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
SUMO1 [nucleoplasm]
(R-HSA-877304)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
0.506
3
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