Tandem pore domain potassium channels

Stable Identifier
R-HSA-1296346
Type
Pathway
Species
Homo sapiens
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Summation

Tandem pore domain K+ channels (K2p) produce leak K+ current which stabilizes negative membrane potential and counter balances depolarization. These channels are regulated by voltage independent mechanisms such as membrane stretch, pH, temperature. Tandem pore domain K+ channels have been classified into six subfamilies; tandem pore domains in weak rectifying K+ channel (TWIK), TWIK-related K+ channel (TREK), TWIK-related acid-sensitive K+ channel (TASK), TWIK-related alkaline pH-activated K+ channel (TALK), tandem pore domain halothane-inhibted K+ channel (THIK), TWIK-releated spinal cord K+ channel).

Literature References
PubMed ID Title Journal Year
20529081 From the background to the spotlight: TASK channels in pathological conditions

Bittner, S, Budde, T, Wiendl, H, Meuth, SG

Brain Pathol 2010
20393194 Molecular background of leak K+ currents: two-pore domain potassium channels

Enyedi, P, Czirják, G

Physiol Rev 2010
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