TWIK-related alkaline pH activated K+ channel (TALK)

Stable Identifier
R-HSA-1299361
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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TWIK-related alkaline pH activated K+ channel (TALK)
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TWIK related alkaline pH activated K+ channels are activated by increase in the extracellular pH. TALK1 and TALK 2 are members of the TALK subfamily and are both are activated by rise in extracellular pH. TALK 2 is expressed in proximal tubule cells and collecting duct cells. TASK 2 is involved in the resorption of bicarbonate.
Literature References
PubMed ID Title Journal Year
20393194 Molecular background of leak K+ currents: two-pore domain potassium channels

Czirják, G, Enyedi, P

Physiol Rev 2010
Participants
Events
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as an event of
Event Information
Go Biological Process
potassium ion transmembrane transport (0071805)
Orthologous Events
TWIK-related alkaline pH activated K+ channel (TALK) (Bos taurus)
TWIK-related alkaline pH activated K+ channel (TALK) (Canis familiaris)
TWIK-related alkaline pH activated K+ channel (TALK) (Gallus gallus)
TWIK-related alkaline pH activated K+ channel (TALK) (Mus musculus)
TWIK-related alkaline pH activated K+ channel (TALK) (Rattus norvegicus)
TWIK-related alkaline pH activated K+ channel (TALK) (Saccharomyces cerevisiae)
TWIK-related alkaline pH activated K+ channel (TALK) (Sus scrofa)
TWIK-related alkaline pH activated K+ channel (TALK) (Xenopus tropicalis)
Authored
Mahajan, SS  (2011-05-22)
Reviewed
Jassal, B  (2010-09-23)
Created
Mahajan, SS  (2011-05-23)
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