Sperm Motility And Taxes

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R-HSA-1300642
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Homo sapiens
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A series of receptor signaling pathways potentially govern chemical communication between sperm and egg, chemotactically guiding incoming sperm towards the oocyte. Though several substances are confirmed as sperm chemoattractant, progesterone (P) seems to be the best chemoattractant candidate for human sperm. Ion channels control the sperm ability to fertilize the egg by regulating sperm maturation in the female reproductive tract and by triggering key sperm physiological responses required for successful fertilization such as hyperactivated motility, chemotaxis, and the acrosome reaction. CatSper, a pH regulated, calcium selective ion channel, potassium channel KSper (Slo3), and Hv1, the voltage gated proton channel are involved in regulation of sperm hyperactivated motility. While progesterone, secreted by ovulated cumulus oophorus, may act as a chemoattractant for sperm cells over the short distances, a major determinant of sperm guidance over long distances in the mammalian female reproductive tract is rheotaxis.

Literature References
PubMed ID Title Journal Year
22017176 The control of male fertility by spermatozoan ion channels

Lishko, PV, Kirichok, Y, Ren, D, Navarro, B, Chung, JJ, Clapham, DE

Annu. Rev. Physiol. 2012
23453951 Rheotaxis guides Mammalian sperm

Miki, K, Clapham, DE

Curr. Biol. 2013
18725941 Progesterone from the cumulus cells is the sperm chemoattractant secreted by the rabbit oocyte cumulus complex

Guidobaldi, HA, Teves, ME, Uñates, DR, Anastasía, A, Giojalas, LC

PLoS ONE 2008
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