Acrosome Reaction and Sperm:Oocyte Membrane Binding

Stable Identifier
R-HSA-1300645
Type
Pathway
Species
Homo sapiens
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The acrosome reaction is stimulated by zona pellucida binding and subsequent downstream events, including Ca2+ influx. Proacrosin cleavage is the hallmark event of the acrosome reaction. After the acrosome reactome the sperm has passed through the cumulus cells and the zona pellucida. The membrane of the sperm head and the membrane of the oocyte are drawn together through the interaction of the sperm-bound protein Izumo and the ooctye CD9 membrane protein.

Literature References
PubMed ID Title Journal Year
20364096 Fertilization: a sperm's journey to and interaction with the oocyte

Ikawa, M, Inoue, N, Benham, AM, Okabe, M

J Clin Invest 2010
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Orthologous Events
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