GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers

Stable Identifier
R-HSA-1306969
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
GRB2:SOS1 complex binds to phosphorylated tyrosine residue Y1139 of ERBB2 in complex with ERBB4.
Literature References
PubMed ID Title Journal Year
8622888 Signal transduction pathways induced by heregulin in MDA-MB-453 breast cancer cells

Cho, C, Sepp-Lorenzino, L, Lupu, R, Eberhard, I, Ma, Z, Serve, H, Liu, F, Rosen, N

Oncogene 1996
Participants
Input
Output
Participates
as an event of
Orthologous Events
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Bos taurus)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Danio rerio)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Drosophila melanogaster)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Gallus gallus)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Mus musculus)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Rattus norvegicus)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Sus scrofa)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-05-28)
Cite Us!