RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers

Stable Identifier
R-HSA-1306972
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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SOS1 bound to GRB2 in complex with any of the phosphorylated ERBB2:ERBB4 heterodimers catalyzes guanyl-nucleotide exchange on RAS, leading to the activation of the MAP kinase cascade.

Literature References
PubMed ID Title Journal Year
8622888 Signal transduction pathways induced by heregulin in MDA-MB-453 breast cancer cells

Sepp-Lorenzino, L, Eberhard, I, Ma, Z, Cho, C, Serve, H, Liu, F, Rosen, N, Lupu, R

Oncogene 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Ras guanyl-nucleotide exchange factor activity of NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created