p130 (RBL2) associates with MuvB to form DREAM complex

Stable Identifier
R-HSA-1362261
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In G0 and early G1, p130 (RBL2) bound to E2F4 or E2F5 and DP1 or DP2 associates with the MuvB complex, consisting of LIN9, LIN37, LIN52, LIN54 and RBBP4 to form evolutionarily conserved DREAM complex. Phosphorylation of LIN52 on serine residue S28 is critical for association of MuvB complex with p130 (RBL2).

Literature References
PubMed ID Title Journal Year
21498570 DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly

Litovchick, L, Florens, LA, Swanson, SK, Washburn, MP, DeCaprio, JA

Genes Dev 2011
17531812 Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence

Litovchick, L, Sadasivam, S, Florens, LA, Zhu, X, Swanson, SK, Velmurugan, S, Chen, R, Washburn, MP, Liu, XS, DeCaprio, JA

Mol Cell 2007
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