Reactome | DYRK1A [nucleoplasm]

DYRK1A [nucleoplasm]

Stable Identifier

R-HSA-1362267

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:Q06787 FMR1

Expand all

External Reference Information

External Reference

UniProt:Q13627 DYRK1A

Gene Names

DYRK1A, DYRK, MNB, MNBH

Chain

chain:1-763

Reference Genes

COSMIC (genes):DYRK1A DYRK1A

dbSNP Gene:1859 DYRK1A

ENSEMBL:ENSG00000157540 DYRK1A

Inferred To

DYRK1A [nucleoplasm] (Bos taurus)

DYRK1A [nucleoplasm] (Caenorhabditis elegans)

DYRK1A [nucleoplasm] (Canis familiaris)

DYRK1A [nucleoplasm] (Danio rerio)

DYRK1A [nucleoplasm] (Drosophila melanogaster)

DYRK1A [nucleoplasm] (Gallus gallus)

DYRK1A [nucleoplasm] (Mus musculus)

DYRK1A [nucleoplasm] (Rattus norvegicus)

DYRK1A [nucleoplasm] (Sus scrofa)

DYRK1A [nucleoplasm] (Xenopus tropicalis)

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61962 DCAF7	2	Unfolded DCAF7 [cytosol] (R-HSA-6813821) DCAF7 [nucleoplasm] (R-HSA-8863312)	0.935	15
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.893	8
UniProt:P63167 DYNLL1	6	DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.798	5
UniProt:Q9BRK4 LZTS2			0.744	6
UniProt:Q9NYF3 FA53C			0.738	5
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.734	5
UniProt:P49354 FNTA	3	FNTA(59-379) [cytosol] (R-HSA-202872) FNTA(1-59) [cytosol] (R-HSA-202869) FNTA(2-379) [cytosol] (R-HSA-2530516)	0.725	5
UniProt:P22694 PRKACB	3	PRKACB [ciliary base] (R-HSA-5610404) PRKACB [cytosol] (R-HSA-57846) PRKACB [nucleoplasm] (R-HSA-111937)	0.725	5
UniProt:Q8NCN4 RN169			0.725	4
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.725	4
UniProt:Q6P1L5 F117B			0.725	4
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.725	5
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.67	4
UniProt:Q12815 TROAP			0.67	4
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.67	4
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.669	3
UniProt:Q86VQ1 GLCI1			0.643	3
UniProt:P10644 PRKAR1A	4	PRKAR1A [cytosol] (R-HSA-57836) PRKAR1A [ciliary base] (R-HSA-5610408) PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713471) PRKAR1A(1-183)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713476)	0.643	3
UniProt:Q5T749 KPRP	1	KPRP [cytosol] (R-HSA-9839614)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.547	3
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.547	2
UniProt:Q70EL1 UBP54			0.547	3
UniProt:Q00610 CLTC	10	CLTC [trans-Golgi network membrane] (R-HSA-5333703) CLTC [cytosol] (R-HSA-8856820) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol] (R-HSA-9710852) CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710854) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9710835) CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710853) CLTC [endolysosome membrane] (R-HSA-8870827) CLTC [clathrin-coated endocytic vesicle membrane] (R-HSA-5138450) CLTC [lysosomal membrane] (R-HSA-2980660) CLTC [plasma membrane] (R-HSA-2980668)	0.547	2
UniProt:Q14008 CKAP5	1	CKAP5 [cytosol] (R-HSA-377729)	0.547	2
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.547	2
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.547	2
UniProt:Q8IYR6 TEFF1			0.547	2
UniProt:P55209 NP1L1			0.547	2
UniProt:Q13114 TRAF3	4	K63polyUb-TRAF3 [cytosol] (R-HSA-936402) TRAF3 [cytosol] (R-HSA-914241) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 R118W [cytosol] (R-HSA-5602321)	0.527	3
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.527	2
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.527	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.527	2
UniProt:P49356 FNTB	1	FNTB [cytosol] (R-HSA-2530482)	0.527	4
UniProt:O60299 LZTS3			0.527	2
UniProt:Q6ZSY5 PPR3F			0.527	2
UniProt:P09496 CLTA	6	CLTA [cytosol] (R-HSA-8856817) CLTA [trans-Golgi network membrane] (R-HSA-5333758) CLTA [endolysosome membrane] (R-HSA-8870825) CLTA [clathrin-coated endocytic vesicle membrane] (R-HSA-5138427) CLTA [lysosomal membrane] (R-HSA-2980595) CLTA [plasma membrane] (R-HSA-2980611)	0.527	2
UniProt:P53350 PLK1	4	PLK1 [cytosol] (R-HSA-164603) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [nucleoplasm] (R-HSA-156720)	0.527	2
UniProt:Q14669 TRIP12	1	TRIP12 [cytosol] (R-HSA-976046)	0.499	2
UniProt:Q9Y6M1 IGF2BP2	1	IGF2BP2 [cytosol] (R-HSA-428302)	0.499	3
UniProt:Q9NZI8 IGF2BP1	1	IGF2BP1 [cytosol] (R-HSA-428366)	0.499	3
UniProt:Q14576 ELAV3			0.499	3
UniProt:O00425 IGF2BP3	1	IGF2BP3 [cytosol] (R-HSA-428313)	0.499	3
UniProt:Q01826 SATB1	5	SATB1 [nucleoplasm] (R-HSA-201593) SATB1(1-254) [nucleoplasm] (R-HSA-352269) SATB1(255-763) [nucleoplasm] (R-HSA-352264) monoSUMO1-K744-SATB1 [nucleoplasm] (R-HSA-4615954) polySUMO2,3-K744-SATB1 [nucleoplasm] (R-HSA-4615978)	0.499	2
UniProt:Q06787 FMR1			0.499	3
UniProt:Q9ULU4 ZMYD8			0.499	2
UniProt:Q12926 ELAVL2	1	ELAVL2 [nucleoplasm] (R-HSA-8850864)	0.499	3
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.483	2
UniProt:Q9NRR4 DROSHA	1	DROSHA [nucleoplasm] (R-HSA-1482510)	0.482	2

Cite Us!