Phosphorylation of LIN52 component of MuvB by DYRK1A

Stable Identifier
R-HSA-1362270
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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LIN52 subunit of MuvB complex is phosphorylated by the protein kinase DYRK1A on the serine residue S28, promoting association of MuvB with p130 (RBL2). From model organism studies, DYRK proteins are known to function in cell cycle regulation, differentiation and stress response.

Literature References
PubMed ID Title Journal Year
21498570 DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly

Litovchick, L, Florens, LA, Swanson, SK, Washburn, MP, DeCaprio, JA

Genes Dev 2011
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of DYRK1A [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created