Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1

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R-HSA-1362300
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Pathway
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Homo sapiens
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In G0 and early G1, expression of E2F target genes such as Cyclin A, E2F1, CDC2 and MYBL2 is inhibited by complexes containing p130 (RBL2) and p107 (RBL1), respectively, and histone deacetylase HDAC1.

Literature References
PubMed ID Title Journal Year
11959842 E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

Rayman, JB, Takahashi, Y, Indjeian, VB, Dannenberg, JH, Catchpole, S, Watson, RJ, te Riele, H, Dynlacht, BD

Genes Dev 2002
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