Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix

Stable Identifier
R-HSA-1362417
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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As inferred from biochemical studies in yeast and phenotypic studies in mouse, Mitoferrin-1 (SLC25A37) and Mitoferrin-2 (SLC25A28) transport ferrous iron across the inner mitochondrial membrane. Mitoferrin-1 is essential for maintaining mitochondrial iron uptake in developing erythroid cells; mitoferrin-2 is ubiquitously expressed. Defects in Mitoferrin-1 and Mitoferrin-2 cause a reduction in mitochondrial iron acquisition and biogenesis of iron-sulfur clusters and heme.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ferrous iron transmembrane transporter activity of Mitoferrin1,2 [mitochondrial inner membrane]
Physical Entity
Activity
Inferred From
Cross References
Rhea
Authored
Reviewed
Created