p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2

Stable Identifier
R-HSA-1363303
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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p130 (RBL2) in complex with E2F4/5 and DP1/2 binds to cyclin A or cyclin E in complex with CDK2 through its conserved LFG pocket domain motif and amino terminus, leading to inhibition of CDK2 kinase activity and suppression of cellular growth.

Literature References
PubMed ID Title Journal Year
9199292 p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity

Woo, MS, Sánchez, I, Dynlacht, BD

Mol Cell Biol 1997
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