p130 (RBL2) binds Cyclin E/A:CDK2

Stable Identifier
R-HSA-1363306
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

p130 (RBL2) is able to bind complexes of CDK2 with either cyclin A or cyclin E through the cyclin-binding LFG motif within the pocket domain, which is conserved in p107 (RBL1) and p21/WAF1/Cip1 family of cyclin-dependent kinases. In addition to LFG motif, amino terminal region of p130 (RBL2), conserved in p107 (RBL1), is necessary for inhibition of CDK2 kinase activity. Presence of E2F is not required for this interaction.

Literature References
PubMed ID Title Journal Year
9199292 p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity

Woo, MS, Sánchez, I, Dynlacht, BD

Mol Cell Biol 1997
Participants
Participant Of
hasEvent
Orthologous Events
Authored
Reviewed
Created