PRLR:JAK2 dimerizes

Stable Identifier
R-HSA-1364044
Type
Reaction [binding]
Species
Homo sapiens
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The prolactin receptor (PRLR) peptide is a single transmembrane domain protein that functions as a dimer. Recent reports suggest that like many other cytokine receptors, the prolactin receptor (PRLR) pre-assembles at the plasma membrane in the absence of ligand (Gadd & Clevenger 2006, Tallet et al. 2011), suggesting that ligand-induced activation involves conformational changes in the preformed receptor dimer (Broutin et al. 2010).

Literature References
PubMed ID Title Journal Year
22649370 Investigation of prolactin receptor activation and blockade using time-resolved fluorescence resonance energy transfer

Tallet, E, Fernandez, I, Zhang, C, Salsac, M, Gregor, N, Ayoub, MA, Pin, JP, Trinquet, E, Goffin, V

Front Endocrinol (Lausanne) 2011
16840534 Ligand-independent dimerization of the human prolactin receptor isoforms: functional implications

Gadd, SL, Clevenger, CV

Mol Endocrinol 2006
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