NR1D1 (REV-ERBA) binds heme, the ARNTL gene, and recruits corepressors.

Stable Identifier
R-HSA-1368069
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NR1D1 (REV-ERBA) binds heme. The NR1D1:heme complex is then able to recruit the corepressors NCoR and HDAC3. Corepressors do not bind NR1D1 in the absence of heme. NR1D1:heme binds a RRE element in the promoter of the ARNTL (BMAL1) gene, recruits corepressors, and represses transcription.

Literature References
PubMed ID Title Journal Year
18006707 Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways

Yin, L, Wu, N, Curtin, JC, Qatanani, M, Szwergold, NR, Reid, RA, Waitt, GM, Parks, DJ, Pearce, KH, Wisely, GB, Lazar, MA

Science 2007
20581824 Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction

Phelan, CA, Gampe RT, Jr, Lambert, MH, Parks, DJ, Montana, V, Bynum, J, Broderick, TM, Hu, X, Williams, SP, Nolte, RT, Lazar, MA

Nat Struct Mol Biol 2010
18037887 Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta

Raghuram, S, Stayrook, KR, Huang, P, Rogers, PM, Nosie, AK, McClure, DB, Burris, LL, Khorasanizadeh, S, Burris, TP, Rastinejad, F

Nat Struct Mol Biol 2007
15761026 The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene

Yin, L, Lazar, MA

Mol Endocrinol 2005
Participants
Participant Of
hasEvent
Authored
Reviewed
Created