Reactome | Expression of SREBF1 (SREBP1)

Expression of SREBF1 (SREBP1)

Stable Identifier

R-HSA-1368081

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

nucleoplasm, endoplasmic reticulum membrane

ReviewStatus

5/5

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The SREBF1 (SREBP1) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. As inferred from mouse, RORA (ROR-alpha) enhances expression of SREBF1. The interaction of SREBF1 with sterol sensors INSIG1 and INSIG2 in the endoplasmic reticulum membrane regulates transactivation by SREBF1 of the genes involved in cholesterol biosynthesis (reviewed in Eberle et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
8156598	SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis Wang, X, Sato, R, Brown, MS, Hua, X, Goldstein, JL	Cell	1994
9062340	Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells Shimomura, I, Shimano, H, Horton, JD, Goldstein, JL, Brown, MS	J Clin Invest	1997
8060328	Sterol mediated regulation of SREBP-1a,1b,1c and SREBP-2 in cultured human cells Kawabe, Y, Honda, M, Wada, Y, Yazaki, Y, Suzuki, T, Ohba, Y, Nabata, H, Endo, A, Matsumoto, A, Itakura, H	Biochem Biophys Res Commun	1994
8402897	SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene Yokoyama, C, Wang, X, Briggs, MR, Admon, A, Wu, J, Hua, X, Goldstein, JL, Brown, MS	Cell	1993