RORA activates gene expression

Stable Identifier
R-HSA-1368082
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

As inferred from mouse, RORA binds ROR elements (ROREs) in DNA and recruits the coactivators PPARGC1A (PGC-1alpha) and p300 (EP300, a histone acetylase) to activate transcription.

Literature References
PubMed ID Title Journal Year
7926749 Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors

Giguère, V, Tini, M, Flock, G, Ong, E, Evans, RM, Otulakowski, G

Genes Dev 1994
Participants
Participant Of
hasEvent
Authored
Reviewed
Created