RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene

Stable Identifier
R-HSA-1368087
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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As inferred from mouse, RORA binds RRE DNA elements and recruits the coactivators PGC-1alpha (PPARGC1A), p300 (EP300, a histone acetylase), and NRIP1. Activation of BMAL1 (ARNTL) expression by ROR-alpha (RORA) is inferred from mouse. In mouse, Rora together with coactivators Ep300 and Ppargc1a bind the promoter of Bmal1 and activate transcription.

Literature References
PubMed ID Title Journal Year
21628546 Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140)

Poliandri, AH, Gamsby, JJ, Christian, M, Spinella, MJ, Loros, JJ, Dunlap, JC, Parker, MG

J. Biol. Rhythms 2011
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